摘要
正常骨代谢是动态调节的周期过程,破骨细胞负责的骨吸收与成骨细胞负责的骨形成相互偶联维持动态平衡。当骨形成和骨吸收的动态平衡被破坏时,就会引起骨量丢失及相关骨病。流行病学证据表明,胆固醇会抑制或促进骨代谢,这取决于胆固醇的种类。胆固醇及其代谢产物通过调节成骨细胞和破骨细胞的分化及活化来影响骨代谢的动态平衡。本文就胆固醇对骨代谢影响的研究进展作一综述。
The normal bone metabolism is a dynamic periodic process,bone resorption and bone formation are performed by osteoclasts and osteoblasts respectively to maintain the dynamic balance.Bone loss and related bone disease occurs when the proper balance of bone formation and bone resorption is disrupted.Epidemiological studies suggests that cholesterol can inhibits or promotes bone metabolism,depending on the type of cholesterol.Cholesterol and its metabolites affect the dynamic balance of bone metabolism by regulating the differentiation and activation of osteoblasts and osteoclasts.This paper reviews the research progress of cholesterol on osteogenesis and osteoclastogenesis in bone metabolism.
作者
徐晓丽
孙迎
丁燕
孟碧莹
向光大
XU Xiaoli;SUN Ying;DING Yan;MENG Biying;XIANG Guangda(The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China;Department of Endocrinology, General Hospital of Central Theater Command of Chinese People’s Liberation Army, Wuhan 430070, China;Wuhan University of Science and Technology, Wuhan 430081, China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2021年第6期895-900,共6页
Chinese Journal of Osteoporosis
基金
国家自然科学基金项目(81570730)。
关键词
胆固醇
骨代谢
成骨细胞
破骨细胞
cholesterol
bone metabolism
osteoblast
osteoclast
