摘要
肺纤维化是一种治愈难度大、死亡率高的慢性进行性间充质性肺疾病,主要是组织的异常修复致胶原异常沉积和肺泡结构紊乱,进而致肺功能进行性障碍的呼吸系统疾病。研究发现,巨噬细胞是具有可塑性和多功能性的免疫细胞群体,在多种疾病中,如心血管疾病、纤维化、癌症中发挥重要的作用。目前,抗纤维化治疗常用的方法有激素类药物、免疫抑制剂、中医药等,但抗纤维化的机制仍不十分清楚。了解巨噬细胞活化及其极化的调控可能为寻找新的治疗手段、设计新的治疗策略提供重要的参考价值。
Pulmonary fibrosis is a chronic progressive mesenchymal lung disease with high mortality and difficulty to cure.It is mainly a respiratory disease caused by abnormal tissue repair,abnormal collagen deposition and alveolar structure disorder,which further leads to progressive pulmonary dysfunction.Macrophages have been found to be a plastic and versatile group of immune cells that play an important role in a variety of diseases,such as cardiovascular disease,fibrosis,and cancer.At present,the commonly used methods of anti-fibrosis treatment are hormone drugs,immunosuppressive drugs,traditional Chinese medicine,etc.,but the mechanism of anti-fibrosis is still not very clear.Understanding the regulation of macrophage activation and its polarization may provide important reference value for finding new treatment methods and designing new treatment strategies.
作者
王莹莹
曾小虎
李瑞琴
Wang Yingying;Zeng Xiaohu;Li Ruiqin(School of Basic Medicine,Henan University of Chinese Medicine,Zhengzhou 450000,China;Academy of Chinese Medicine Sciences,Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2021年第4期1193-1199,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
河南省中医药管理局河南省中医药研究专项课题普通课题(2017ZY2109):栝楼薤白汤含药血清抗博来霉素诱导的大鼠肺泡巨噬细胞致纤维化作用及机制研究,负责人:孙春霞,李瑞琴
河南省教育厅河南省高等学校重点科研项目(17A310020):瓜蒌薤白汤通过JNK/P38MAPK途径对人肺泡上皮细胞上皮间质转化的干预作用,负责人:李瑞琴
河南中医药大学科研创新项目重点项目(2019KYCX007):基于内质网应激JNK途径探讨黄芩苷对M2型巨噬细胞的作用及机制研究,负责人:王莹莹。
关键词
巨噬细胞
巨噬细胞极化
肺纤维化
Macrophages
Macrophage polarization
Pulmonary fibrosis
