摘要
目的探讨舒血宁注射液联合巴丝肼治疗帕金森病的疗效,及对脑区血流量与血清炎性因子水平的影响。方法抽取2017年9月至2019年8月在寿光市中医医院治疗的78例帕金森病患者为研究对象,按照随机数字表法将其分为对照组和观察组,每组39例。对照组使用多巴丝肼治疗;观察组在对照组治疗基础上联合舒血宁注射液治疗。比较两组临床疗效、不良反应、脑区血流量及炎性因子水平。结果观察组总有效率为87.18%(34/39),高于对照组的66.67%(26/39),差异有统计学意义(P<0.05)。治疗后,观察组双侧颞叶、额叶、基底节区血流量均高于对照组(P均<0.05),血清白细胞介素-6、高敏C反应蛋白、肿瘤坏死因子-α水平均低于对照组(P均<0.05)。治疗后,观察组不良反应发生率(12.82%,4/39)与对照组(15.38%,6/39)比较差异未见统计学意义(P>0.05)。结论舒血宁注射液联合多巴丝肼治疗帕金森病可有效改善患者脑区血流量,降低炎性因子水平,提高总有效率,且用药安全性良好。
Objective To investigate the effect of Shuxuening injection combined with dopaserizide in the treatment of Parkinson’s disease,and its influence on cerebral blood flow and serum inflammatory factors level.Methods A total of 78 patients with Parkinson’s disease treated in Shouguang Hospital of Traditional Chinese Medicine from September 2017 to August 2019 were selected.And they were divided into control group and observation group by random number table method,with 39 cases in each group.The control group was treated with dopaserizide;while the observation group was treated with Shuxuening injection based on the treatment of control group.The clinical efficacy,adverse reactions,cerebral blood flow,and levels of inflammatory factors were compared between the two groups.Results The total effective rate of the observation group was 87.18%(34/39),higher than the 66.67%(26/39)of the control group(P<0.05).After treatment,the blood flow volumes in the bilateral temporal lobes,bilateral frontal lobes,and basal ganglia of the observation group were significantly higher than those of the control group(P<0.05).After treatment,levels of serum interleukin-6,high sensitivity C-reactive protein,and tumor necrosis factor-αin the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in incidence of adverse reaction between the observation group(12.82%,4/39)and the control group(15.38%,6/39),P>0.05.Conclusions The combined application of Shuxuening injection and dopasrazide,in the treatment of Parkinson’s disease,can effectively improve the blood flow in the brain area,reduce the level of inflammatory factors,increase the total effective rate,with high safety.
作者
杨艳萍
刘廷涛
吴涛
Yang Yanping;Liu Tingtao;Wu Tao(The First Department of Encephalopathy,Shouguang Hospital of Traditional Chinese Medicine,Shouguang 262700,China)
出处
《中国实用医刊》
2021年第9期90-93,共4页
Chinese Journal of Practical Medicine
关键词
帕金森病
舒血宁注射液
炎性因子
脑区血流量
Parkinson’s disease
Shuxuening injection
Inflammatory factor
Cerebral blood flow
