摘要
目的:系统评价中药联合芬吗通治疗围绝经期综合征的效果。方法:计算机检索中国知网(CNKI)、万方数据医学信息系统(WF)、维普网(VIP)、中国生物医学文献数据库(CBM)、Embase、Pubmed、Coehrane Library自建库至2020年3月28日的中药联合芬吗通治疗围绝经期综合征文献,用Cochrane系统评价文献质量、RevMan 5.3软件进行Meta分析。结果:纳入文献9篇,共1063例患者(对照组519例,试验组544例),中药联合芬吗通比单纯芬吗通治疗围绝经期综合征能显著提高总有效率(P<0.01),改善血清FSH、LH、E 2水平(P<0.01),改善kupperman评分(P<0.01),不良反应发生率试验组为3.44%,对照组为8.52%。结论:中药联合芬吗通比单纯芬吗通治疗围绝经期综合征在提高总有效率、改善性激素水平、改善kupperman评分,降低不良反应等方面有明显优势。
Objective Toevaluatethe effect of traditional Chinese medicine combined with femoston on perimenopausal syndrome.Methods A computer search for relevant articles was run on China National Knowledge Infrastrucure,Wanfang Data,VIP China Science and Technology Journal database,Chinese Biomedical Literature Database,Pubmed,Embase.Retrieval time limit was from the database—established year to March 28th,2020.Two reviewers assessed the methodological quality according to Cochrane Systematic Review independently.Meta analysis was performed with RevMan 5.3 software.Results A total of 9 articles involving 1063 patients were included(544 in the experimental group,519 in the control group).Chinese medicine combined with femoston for perimenopausal syndrome could significantly improve the total effective rate(P<0.01),improve follicle-stimulating hormone level(P<0.01)、luteinizing hormone level(P<0.01)、and estriol level(P<0.01),andimprove the Kuppermanscore(P<0.01).The incidence of adverse drug reactions was 3.44%in the experimental group and 8.52%in the control group.Conclusions Chinese medicine combined with femoston has an advantage in the treatment of perimenopausal syndrome over femoston alone in total effective rate,improving sex hormone levels,improve the Kupperman score,and reducing the risk of adverse drug reaction.
作者
王山云
罗颂平
曾诚
曾建峰
陈思达
刘耀平
WANG Shanyun;LUO Songping;ZENG Cheng;ZENG Jianfeng;CHEN Sida;LIU Yaoping(Zhongshan hospital of traditional chinese medicine,Zhongshan 528400,China;The First Affiliated Hospital of Guangzhou University of Traditional ChineseMedicine,Guangzhou 510405,China;Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006,China)
出处
《中国民族民间医药》
2021年第11期51-57,共7页
Chinese Journal of Ethnomedicine and Ethnopharmacy
