摘要
目的:了解磷酸氯喹在治疗新型冠状病毒肺炎(COVID-19)患者过程中的安全性,为COVID-19临床用药安全性提供参考。方法:回顾性分析2020年2月3日至3月1日十堰市第二定点救治医院收治的50例经口服磷酸氯喹治疗的新型冠状病毒肺炎患者,统计分析患者在口服磷酸氯喹后主要不良反应发生情况。结果:50例经磷酸氯喹治疗的患者中,有32例发生不良反应,最常见的不良反应为神经系统症状,头晕8例次(16%),震颤8例次(16%),失眠6例次(12%),头痛2例次(4%),其次为胃肠道症状恶心8例次(16%)、腹泻6例次(12%)、腹痛2例次(4%),有24例(48%)患者出现转氨酶升高,经对症处理后患者不良反应症状均消失、肝功能恢复正常。结论:磷酸氯喹治疗COVID-19患者可能出现一些比较常见的不良反应,但严重不良反应发生率较低,可在严密观察患者不良反应的情况下使用磷酸氯喹治疗COVID-19患者。
Objective To investigate the safety of chloroquine phosphate in the treatment of patients with novel coronavirus pneumonia,and provide a reference for the safety of COVID-19 clinical medication.Methods A retrospective analysis of 50 cases of novel coronavirus pneumonia treated with oral chloroquine phosphate in the second designated treatment hospital of Shiyan City from February 3 to March 1,2020 was conducted.The main adverse reactions after oral chloroquine treat⁃ment were analyzed statistically.Results Of the 50 patients treated with chloroquine phosphate,32 had adverse reactions.The most common adverse reactions were neurological symptoms,8 cases of dizziness(16%),8 cases of tremor(16%),6 cases of insomnia(12%),and 2 cases of headache(4%),followed by gastrointestinal symptoms nausea 8 cases(16%),diarrhea 6 cases(12%)and abdominal pain 2 case(4%).24 cases(48%)of the patients had elevated transam⁃inase.After symptomatic treatment,the adverse reaction symptoms disappeared and the liver function returned to normal.Conclusion Chloroquine phosphate may cause some common adverse reactions in the treatment of patients with novel coro⁃navirus pneumonia,but the incidence of serious adverse reactions is low.Chloroquine phosphate can be safely used to treat patients with novel coronavirus pneumonia under close observation of adverse reactions.
作者
郭功兵
梁惠
刘玉全
屈红
张小乔
GUO Gong-bing;LIANG Hui;LIU Yu-quan;QU Hong;ZHANG Xiao-qiao(Department of Geriatrics,Taihe Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China)
出处
《湖北医药学院学报》
CAS
2021年第3期277-280,共4页
Journal of Hubei University of Medicine
基金
十堰市新冠肺炎应急科研项目(20Y17)。
关键词
磷酸氯喹
新型冠状病毒肺炎
安全性
Chloroquine phosphate
Novel coronavirus pneumonia(COVID-19)
Adverse drug reactions
