摘要
铁死亡(ferroptosis)是一种近期发现的细胞程序性死亡方式,主要是由细胞内铁依赖的脂质过氧化物蓄积所致,其在形态、生物化学和基因方面与既往常见的细胞凋亡、坏死和自噬等方式有较大差别。细胞的程序性死亡在促进人体发育以及维持内环境平衡方面具有至关重要的作用。近几年研究发现,铁死亡与神经系统退行性疾病、脑血管硬化及脑部肿瘤等疾病的发生发展紧密相关,这可能为神经系统疾病的机制研究和药物治疗提供新的方向和靶点。本文将系统阐述铁死亡的相关机制及其在神经系统疾病的发生发展中的重要作用。
Ferroptosis is a recently discovered manner of cell procedural death,which is mainly attributable to the accumulation of lipid peroxides dependent on intracellular iron.Ferroptosis is greatly different from in morphological,biochemical and genetic aspects.Programmed cell death is crucial in promoting human development and maintaining the balance of internal environment.Recent studies have found that ferroptosis is closely related to the development of degenerative diseases in the nervous system,cerebrovascular sclerosis and brain tumors,which may provide a new direction and targets for exploring the mechanisms of nervous system diseases and drug treatment.The current review is to summarize the mechanism of ferroptosis and its important role in the development of neurological diseases.
作者
张珂嘉
蒋诗敏
周瑶
武琦
刘超侠
王影
王忠诚
李俐
ZHANG Kejia;JIANG Shimin;ZHOU Yao;WU Qi;LIU Chaoxia;WANG Ying;WANG Zhongcheng;LI Li(Department of Pathophysiology,Xuzhou Medical University,Xuzhou,Jiangsu 221004,China;Department of Physiology,Xuzhou Medical University)
出处
《徐州医科大学学报》
CAS
2021年第5期380-385,共6页
Journal of Xuzhou Medical University
基金
国家自然科学基金(81801168)
江苏省自然科学基金(BK20160228)。
