摘要
目的:探讨CD20阳性的结外鼻型NK/T细胞淋巴瘤(ENKTL)的临床特征及预后。方法:对11例ENKTL患者的临床特征及预后进行分析。结果:11例患者中,乳酸脱氢酶升高者6例,贫血者6例,Ki-67≥50%者8例,2例随访中;1例失联;8例死亡,平均生存时间为22.5个月。结论:CD20阳性的ENKTL诊断存在困难,需联合病理形态学、免疫组织化学、EBER及基因重排检测,提高对该病的认识,早期诊断,积极治疗。
Objective:To explore the clinical features and prognosis of CD20-positive extranodal NK/T cell lymphoma.Methods:To analyze the clinical characteristics and prognosis of 11 ENKTL patients admitted to this hospital.Results:Among the 11 patients,6 cases with elevated LDH,6 cases of anemia,and 8 cases with Ki-67≥50%.Two cases survived;1 case lost contact;8 cases died,and the average survival time of 8 cases was 22.5 months.Conclusion:The diagnosis of CD20 positive ENKTL is difficult,which requires a combination pathomorphology,immunohistochemistry,EBER and gene rearrangement detection and improve the understanding of the disease.Early diagnosis and active treatment is important.
作者
杨双双
巴云鹏
姜国忠
YANG Shuangshuang;BA Yunpeng;JIANG Guozhong(Department of Rhinology,First Affiliated Hospital,Zhengzhou University,Zhengzhou,450052,China;Department of Pathology,First Affiliated Hospital,Zhengzhou University)
出处
《临床耳鼻咽喉头颈外科杂志》
CSCD
北大核心
2021年第5期436-440,共5页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
