摘要
目的探讨血清中血管紧张素转换酶(ACE)和血管紧张素原(AGT)与妊娠期高血压综合征(HDCP)的相关性及HDCP发病的危险因素。方法选择135例妊娠高血压患者(HDCP组)和100例正常孕妇(CK组),用ELISA法检测各组的血清ACE、AGT水平,并进行相关性分析;抽取两组孕产妇的年龄、怀孕天数、孕前体质量指数(BMI)、产次、产检次数、高血压糖尿病家族史、文化程度等一般资料,对孕产妇患HDCP的危险因素进行单因素分析,将单因素回归分析中有统计学意义的因素进行多因素Logistic回归分析。结果 HDCP组血清ACE水平(90.49±47.65)μg/L明显高于CK组(58.72±27.58)μg/L,P <0.05,差异有统计学意义;HDCP组血清AGT水平(64.57±19.71)μg/L高于CK组(58.22±18.64)μg/L,P> 0.05,差异无统计学意义;单因素分析结果显示,年龄、BMI、高血压、糖尿病家族史、ACE水平是孕产妇患HDCP的危险因素(P<0.05),怀孕天数、产次、产检次数、文化程度比较差异无统计学意义(P>0.05);多因素分析显示:年龄、BMI、高血压糖尿病史、ACE水平是妊娠性高血压的危险因素。结论 ACE水平与HDCP有关,AGT水平与HDCP无关;年龄大、BMI值高、有高血压糖尿病史者,ACE水平增高发生妊娠高血压综合征的风险增加。
Objective To investigate the relationship between serum angiotensin converting enzyme(ACE) and angiotensinogen(AGT) and gestational hypertension syndrome(HDCP) and the risk factors of HDCP.Methods A total of 135 pregnant hypertensive patients(HDCP group) and 100 normal pregnant women as control check(CK) group were selected.Serum ACE and AGT levels were measured by ELISA,and correlation analysis was performed.The age and gestational age of the two groups,pre-pregnancy body mass index(BMI),parity,number of births,family history of hypertension,family history,education,and other general information,single factor analysis of risk factors for maternal HDCP,single factor regression analysis Statistically significant factors were all used for multivariate logistic regression analysis.Results The serum ACE level in the HDCP group(90.49±47.65) μg/L was significantly higher than that in the CK group(58.72±27.58) μg/L,P< 0.05,the difference was statistically significant.The serum AGT level in the HDCP group was(64.57±19.71) μg/L was higher than CK group(58.22±18.64) μg/L,P>0.05,the difference was not statistically significant;single factor analysis showed: age,BMI,hypertension,family history of diabetes,ACE level was maternal(P<0.05),while gestational age,parity,number of births,and education were no significant differences in risk factors for HDCP(P>0.05).Multivariate analysis showed: age,BMI,history of hypertension and ACE.It was a risk factor for pregnancy-induced hypertension.Conclusion ACE levels are associated with HDCP.AGT levels are not associated with HDCP.Patients with a high age,high BMI,and hypertension history have an increased risk of gestational hypertension syndrome.
作者
王茹
庄文婷
王香林
李红荣
李长兴
孔德霞
李建华
WANG Ru;ZHUANG Wen-ting;WANG Xiang-lin;LI Hong-rong;LI Chang-xing;KONG De-xia;LI Jian-hua(Department of Human Anatomy,Basic Medicine Science,Medical College of Qinghai University,Xining 810001,China;Department of Radiology,Huadu District People’s Hospital,Guangzhou Huadu 510800,China;Department of Surgical,Gansu Wuwei Tumor Hospital,Gansu Wuwei 733000,China;Department of Gynecology,the Second People’s Hospital of Xining City,Xining 810001,China)
出处
《解剖学报》
CAS
CSCD
北大核心
2021年第3期460-464,共5页
Acta Anatomica Sinica
基金
青海省科技厅计划项目(2019-SF-134)。
