摘要
位于新生和成年哺乳动物延髓腹外侧区的前包钦格复合体被认为是呼吸节律产生的中枢.正常状态下呼吸节律是均匀而整齐的,而病理状态下呼吸节律会发生变化,因此研究呼吸节律产生的动力学机制及其控制有重要意义.本文基于前包钦格复合体中胞体-树突耦合神经元模型,利用相平面分析、分岔分析、快慢动力学分析以及ISI(峰峰间期)分岔序列等方法,研究了在钙离子动力学及LIP3(内质网泄漏渗透率)的影响下,LIP3的变化对耦合前包钦格复合体神经元放电节律的重要影响,并研究了模型中反相簇放电的模式及其转迁机制.结果表明,钙的周期性波动是混合簇放电产生的关键因素,但不是混合簇放电产生的必要条件.本文的研究方法也可以应用于其他多时间尺度的神经系统中.
The pre-B?tzinger complex,which is located at a ventrolateral medulla of human and mammal,is considered to be the center for the generation of respiratory rhythms.In a normal state,the respiratory rhythm is uniform and orderly.Otherwise,the respiratory rhythm will change to a pathological state.Therefore,the monitoring of respiratory rhythm is of great significance in monitoring the health.In this paper,according to a two-coupled model of pre-B?tzinger complex with calcium ion current,we investigate the generation and transition mechanism of anti-phase bursting synchronization by using phase-plane analysis,bifurcation and fastslow decomposition.It is found that the pre-B?tzinger complex model can exhibit mixed bursting when calcium ion concentration is at steady state,which indicates that the oscillation of calcium is not a necessary condition for the generation of mixed bursting.This is quite different from the results obtained in previous studies,indicating that the mixed bursting is caused by the periodic fluctuations of calcium.The methods used in this paper can provide a new idea for investigating the dynamics of mixed bursting,and it can also be applied to the study of other neuronal systems on a multiple time scale.
作者
赵雅琪
刘谋天
赵勇
段利霞
Zhao Ya-Qi;Liu Mou-Tian;Zhao Yong;Duan Li-Xia(School of Science,North China University of Technology,Beijing 100144,China;School of Mathematics and System Science,Guangdong Technical Normal University,Guangzhou 510665,China)
出处
《物理学报》
SCIE
EI
CAS
CSCD
北大核心
2021年第12期30-40,共11页
Acta Physica Sinica
基金
国家自然科学基金(批准号:11872003)
北方工业大学“特色学科建设”项目(批准号:110052972027/014)资助的课题。
关键词
前包钦格复合体
混合簇放电
分岔
快慢分析
pre-B?tzinger complex
mixed bursting
bifurcation
fast-slow analysis
