摘要
目的探讨2019新型冠状病毒肺炎(COVID-19)普通型患者的临床特征及部分肝、肾、心功能实验室检测结果。方法选取COVID-19普通型患者330例作为研究对象,收集所有患者的一般临床资料;抽取患者清晨空腹肘静脉血3 mL,离心后上机检测肝功能指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、γ-谷氨酰转肽酶(GGT)、总胆红素(TBIL)、总胆汁酸(TBA)、总蛋白(TP)、白蛋白(ALB)及前白蛋白(PA)]、肾功能指标[尿素(Urea)、肌酐(Crea)、胱抑素C(Cysc)及β2微球蛋白(β2-MG)]及心功能指标[肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)及α-羟丁酸脱氢酶(HBDH)],并统计各指标的异常情况。结果患者临床症状以发热、咳嗽最多见,其次有胸闷和乏力,少数患者有畏寒、咽部不适、头晕头痛、肌痛、腹痛腹泻及恶心呕吐等症状,男性和女性患者发生咳嗽和肌痛比例差异有统计学意义(P<0.05);患者肝、肾、心功能相关指标均有不同程度的异常,异常率在10%以上的指标有ALT(21.8%)、AST(17.9%)、GGT(22.4%)、TP(29.1%)、ALB(57.6%)、PA(17.6%)、β2-MG(10.0%)、LDH(21.4%)及HBDH(14.9%);男性和女性患者ALT、GGT及CK异常率差异有统计学意义(P<0.05)。结论COVID-19普通型患者临床表现以发热和咳嗽为主,患者存在肝、肾及心功能的轻微受损。
Objective Statistical analysis of the clinical characteristics and part laboratory test results of ordinary patients with corona virus disease 2019(COVID-19).Methods The general clinical data of 330 cases with COVID-19 were collected.3 mL of fasting cubital venous blood was drawn from all cases in the morning,centrifuged and tested for biochemical indicators,including liver function indicators[alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),γ-glutamyl transpeptidase(GGT),total bilirubin(TBIL),total bile acid(TBA),total protein(TP),albumin(ALB),prealbumin(PA)],kidney function indicators[carbamide(Urea),creatinine(Crea),cystatin C(Cysc),β2 microglobulin(β2-MG)]and cardiac function indicators[creatine kinase(CK),creatine kinase isoenzymes(CK-MB),lactate dehydrogenase(LDH),alpha-hydroxybutyrate dehydrogenase(HBDH)],and the abnormal rates of each indicator were detected.Results The clinical symptoms of the cases were fever and cough,followed by chest tightness and fatigue.A small number of cases have symptoms of chills,throat discomfort,dizziness,headache,myalgia,abdominal pain,diarrhea,nausea and vomiting.There was a statistically significant difference in the occurrence of cough and myalgia between the male and female cases(P<0.05).The abnormal rates of liver function indexes greater than 10%including ALT(21.8%),AST(17.9%),GGT(22.4%),TP(29.1%),ALB(57.6%),PA(17.6%),β2-MG(10.0%),LDH(21.4%),and HBDH(14.9%).There was a statistically significant difference in the abnormal rates of ALT,GGT and CK between the male and female(P<0.05).Conclusion The clinical symptoms of ordinary patients with COVID-19 are mainly fever and cough.COVID-19 cases may have slight damages of liver,renal and cardiac functions.
作者
黄赟
程树强
马红星
程安南
严松盛
邵媛
韩卉
莫非
HUANG Yun;CHENG Shuqiang;MA Hongxing;CHENG Annan;YAN Songsheng;SHAO Yuan;HAN Hui;MO Fei(Center of Clinical Laboratory,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China;Department of Laboratory,Ezhou Third Hospital,Ezhou 436001,Hubei,China)
出处
《贵州医科大学学报》
CAS
2021年第6期739-744,共6页
Journal of Guizhou Medical University
基金
贵州省卫生健康委科学技术基金项目[gzwjkj2020-1-242]。
关键词
肺炎
2019新型冠状病毒肺炎
临床特征
生化指标
肝功能
肾功能
心功能
pneumonia
corona virus disease 2019(COVID-19)
clinical features
biochemical indicators
liver functions
renal functions
cardiac functions
