摘要
三氯乙烯(TCE)是工业中常用的有机溶剂,已被国际癌症研究机构(IARC)列为Ⅰ类致癌物,并具有免疫毒性、肝脏毒性、肾脏毒性和神经毒性等。越来越多的证据表明,TCE所致的自身免疫性疾病和癌症与表观遗传修饰有关。本文基于TCE在表观遗传修饰方面的最新研究进展,对TCE引起DNA甲基化、组蛋白修饰和微小RNA调控等进行综述,为进一步探究TCE暴露影响健康的机制提供信息。
Trichloroethylene(TCE)is a commonly used organic solvent in industry and it was classified as a Group I carcinogen by IARC,with immunotoxicity,hepatotoxicity,kidney toxicity and neurotoxicity.Increasing evidence suggests that TCE-induced autoimmune diseases and cancer are involved in epigenetic modifications.This paper summarized the mechanism of DNA methylation,histone modification and microRNA in toxicity of TCE according to the newly published articles,so as to provide new ideas for further revealing the mechanism of TCE exposure affecting health.
作者
黄华
张家祥
朱启星
Huang Hua;Zhang Jiaxiang;Zhu Qixing(Department of Occupational and Environmental Health,School of Public Health,Anhui Medical University,Hefei 230032,China;Institute of Dermatology,the First Affiliated Hospital of Anhui Medical University,Hefei 230000,China)
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2021年第5期385-389,共5页
Chinese Journal of Industrial Hygiene and Occupational Diseases
基金
国家自然科学基金项目(81874259、81673141)
安徽省自然科学基金(2008085QH385)。
