摘要
核仁小RNA(snoRNA)是非编码RNA(ncRNA)中的一类,主要参与核糖体RNA转录过程的修饰。snoRNA是某些微小RNA的前体,也可由长链非编码RNA进一步加工而来;此外,snoRNA也是参与细胞各种生理和病理过程的重要调控分子。snoRNA与肿瘤及其他多种疾病的发生、发展、预后不良息息相关,甚至可以作为潜在的治疗靶点。该文就snoRNA的基础结构、生物学功能、检测方法、相关数据库,以及snoRNA在肿瘤及其他多种疾病中的研究进展进行综述。
Small nucleolar RNA(snoRNA)is a type of non-coding RNA(ncRNA),mainly involved in the modification of ribosomal RNA transcription.SnoRNA is the precursor of certain microRNAs,and can also be further processed from long non-coding RNA.In addition,snoRNA is an important regulatory molecule involved in various physiological and pathological processes of cells.SnoRNA is closely related to the occurrence,development and poor prognosis of tumors and many other diseases,and can even be used as a potential therapeutic target.This article reviews the basic structure,biological functions,detection methods,related databases of snoRNA and the research progress of snoRNA in tumors and many other diseases.
作者
孙洁璇
高卓(综述)
姜晓峰(审校)
SUN Jiexuan;GAO Zhuo;JIANG Xiaofeng(Department of Clinical Laboratory,the Fourth Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150028,China)
出处
《国际检验医学杂志》
CAS
2021年第12期1513-1517,共5页
International Journal of Laboratory Medicine
基金
国家自然科学基金青年基金项目(81502587)。
