摘要
目的探讨CYP2C19基因多态性与急性非静脉曲张性上消化道出血(ANVUGIB)患者预后的关系。方法选取2019年4月至2020年4月该院收治的114例ANVUGIB患者为研究对象,根据预后情况将患者分为死亡组44例和存活组70例。采用实时荧光定量PCR检测CYP2C19基因多态性。比较两组患者临床资料、CYP2C19基因检测结果。采用多因素Logistic回归分析ANVUGIB患者死亡的危险因素。采用受试者工作特征曲线分析CYP2C19基因多态性对ANVUGIB患者死亡风险的预测价值。结果与存活组比较,死亡组CYP2C19*1/*1基因型、CYP2C19*1等位基因频率更低,CYP2C19*1/*2基因型、CYP2C19*1/*3基因型及CYP2C19*2等位基因频率更高,差异有统计学意义(P<0.05)。年龄>65岁、内镜下见活动性出血、输血、再出血、CYP2C19*1/*2基因型、CYP2C19*1/*3基因型和CYP2C19*2等位基因是ANVUGIB患者死亡的危险因素(P<0.05)。CYP2C19*1、*2和*3等位基因预测ANVUGIB患者死亡的曲线下面积分别为0.705、0.767、0.678。结论CYP2C19基因多态性与ANVUGIB患者预后有关,CYP2C19*1/*2基因型、CYP2C19*1/*3基因型和CYP2C19*2等位基因是影响患者预后的危险因素。
Objective To explore the relationship between CYP2C19 gene polymorphism and the prognosis of patients with acute non-varices upper gastrointestinal bleeding(ANVUGIB).Methods A total of 114 ANVUGIB patients admitted to the hospital from April 2019 to April 2020 were selected as the research objects.According to the prognosis,the patients were divided into the death group of 44 cases and the survival group of 70 cases.Real-time fluorescent quantitative PCR was used to detect CYP2C19 gene polymorphism.Compared the clinical data and CYP2C19 gene detected results between the two groups.Multivariate Logistic regression was used to analyze the risk factors of death in ANVUGIB patients.The receiver operating characteristic curve was used to analyze the predictive value of CYP2C19 gene polymorphism on the risk of death in ANVUGIB patients.Results Compared with the survival group,the CYP2C19*1/*1 gene type,CYP2C19*1 allele frequency were lower in the death group,and the CYP2C19*1/*2 gene type,CYP2C19*1/*3 gene type and CYP2C19*2 allele frequency were higher in the death group,the difference was statistically significant(P<0.05).Age>65 years old,active bleeding seen under endoscopy,blood transfusion,rebleeding,CYP2C19*1/*2 gene type,CYP2C19*1/*3 gene type and CYP2C19*2 allele were risk factors for death in ANVUGIB patients(P<0.05).The area under the curve of CYP2C19*1,*2 and*3 alleles predicting death of ANVUGIB patients were 0.705,0.767 and 0.678 respectively.Conclusion CYP2C19 gene polymorphism is related to the prognosis of patients with ANVUGIB.CYP2C19*1/*2 gene type,CYP2C19*1/*3 gene type and CYP2C19*2 allele are risk factors affecting the prognosis of patients.
作者
王芬
张蓉
姚亚维
闫再宏
WANG Fen;ZHANG Rong;YAO Yawei;YAN Zaihong(Department of Gastroenterology,Hebei Petro China Central Hospital,Langfang,Hebei 065000,China)
出处
《国际检验医学杂志》
CAS
2021年第12期1477-1480,共4页
International Journal of Laboratory Medicine
基金
河北省廊坊市科学技术研究与发展计划自筹经费项目(2020013090)。
