摘要
疱疹样皮炎是一种与乳糜泻相关的自身免疫性大疱病,多发于携带HLA?DQ2或HLA?DQ8等位基因的高加索人。研究表明,疱疹性皮炎患者血清中存在多种针对转谷氨酰胺酶等抗原的抗体,表皮型转谷氨酰胺酶是其自身抗原。疱疹样皮炎的发病除与遗传和麦胶敏感有关外,还可能与肠道菌群微生态失衡有关。无麦胶饮食和氨苯砜仍然是疱疹样皮炎的主要治疗手段。本文从流行病学、发病机制、临床表现、实验室检查、诊断及治疗等方面对疱疹样皮炎进行总结。
Dermatitis herpetiformis is an autoimmune bullous disease associated with celiac disease,which occurs mostly in Caucasians carrying HLA-DQ2 or HLA-DQ8 alleles.Studies have shown a variety of antibodies against transglutaminase and other antigens in the serum of patients with dermatitis herpetiformis,and epidermal transglutaminase is an autoantigen.The occurrence of dermatitis herpetiformis is not only associated with genetics and gluten sensitivity,but may also be related to the imbalance of intestinal microbiome.Gluten-free diet and dapsone are still the main therapies for dermatitis herpetiformis.This review summarizes epidemiological features,pathogenesis,clinical manifestations,laboratory findings,diagnosis and treatment of dermatitis herpetiformis.
作者
曹珊
杨宝琦
Cao Shan;Yang Baoqi(Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venereology,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250022,China)
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2021年第6期549-553,共5页
Chinese Journal of Dermatology
关键词
疱疹样皮炎
乳糜泻
诊断
治疗
发病机制
血清学试验
Dermatitis herpetiformis
Celiac disease
Diagnosis
Therapy
Pathogenesis
Serologic tests
