摘要
目的:观察督灸联合补肾祛寒化湿方对强直性脊柱炎(AS)的临床疗效及对患者血清Ⅰ-型胶原蛋白C末端肽(CTX-Ⅰ)、Dickkopf1蛋白(DKK1)水平的影响。方法:选取160例AS患者,按信封抽签法分为A组、B组、C组及D组,每组40例。A组给予常规西药对症治疗,B组在A组基础上联合督灸治疗,C组在A组基础上联合补肾祛寒化湿方治疗,D组在A组基础上给予督灸联合补肾祛寒化湿方治疗,疗程均为3个月。比较4组中医证候积分、治疗前后症状改善情况及血沉(ESR)、C-反应蛋白(CRP)、CTX-Ⅰ、DKK1水平。结果:治疗后,4组中医证候积分均较治疗前降低(P<0.05),中医证候积分从低至高依次为D组、C组、B组、A组,D组中医证候积分明显低于A组、B组及C组(P<0.05)。治疗后,4组胸廓活动度均较治疗前增大(P<0.05),胸廓活动度从大到小依次为D组、C组、B组、A组;4组枕墙距、指地距均较治疗前缩小(P<0.05),巴氏强直性脊柱炎活动指数(BASDAI)及巴氏强直性脊柱炎功能指数(BASFI)均较治疗前降低(P<0.05),D组枕墙距、指地距、BASDAI及BASFI均低于A组、B组及C组(P<0.05),B组及C组枕墙距、指地距、BASDAI及BASFI均低于A组(P<0.05)。治疗后,4组ESR、CRP、CTX-Ⅰ、DKK1水平均较治疗前降低(P<0.05),D组ESR、CRP、CTX-Ⅰ、DKK1水平均低于A组、B组及C组(P<0.05),B组及C组ESR、CRP、CTX-Ⅰ、DKK1水平均低于A组(P<0.05)。结论:督灸联合补肾祛寒化湿方可减轻AS患者的炎症反应,调节CTX-Ⅰ、DKK1表达,改善机体活动功能。
Objective:To observe the clinical effect of moxibustion at governor vessel combined with Bushen Quhan Huashi prescription for ankylosing spondylitis(AS)and its effect on levels of C-terminal telopeptide of typeⅠcollagen(CTX-I)and Dickkopf-1 protein(DKK1)in serum.Methods:A total of 160 cases of AS patients were selected and divided into group A,group B,group C and group D by envelope method,40 cases in each group.Group A was given routine symptomatic treatment of western medicine;group B was additionally treated with moxibustion at governor vessel based on the treatment of group A;group C was additionally treated with Bushen Quhan Huashi prescription based on the treatment of group A;group D was additionally treated with moxibustion at governor vessel and Bushen Quhan Huashi prescription based on the treatment of group A.All groups were treated for three months.The Chinese medicine syndrom score was compared among the four groups.The improvement of symptoms before and after treatment as well as levels of erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),CTX-I and DKK1 were compared among the four groups.Results:After treatment,the Chinese medicine syndrome scores in the four groups were decreased when compared with those before treatment(P<0.05);and the groups with the scores from low to high were group D,group C,group B and group A;the score in group D was significantly lower than those in group A,group B and group C(P<0.05).After treatment,thoracic mobility in the four groups were increased when compared with those before treatment(P<0.05);and the groups with the thoracic mobility from large to small were group D,group C,group B and group A;occiput-to-wall distance and finger-to-floor distance in the four groups were decreased when compared with those before treatment(P<0.05).Bath Ankylosing Spondylitis Disease Activity Index(BASDAI)and Bath Ankylosing Spondylitis Functional Index(BASFI)in the four groups were decreased when compared with those before treatment(P<0.05).After treatment,occiput-to-wall
作者
郭利娟
韩崇涛
阎晓霞
葛飞
赵永杰
徐迎锋
朱紫燕
GUO Lijuan;HAN Chongtao;YAN Xiaoxia;GE Fei;ZHAO Yongjie;XU Yingfeng;ZHU Ziyan
出处
《新中医》
CAS
2021年第10期117-121,共5页
New Chinese Medicine
基金
河南省中医药科学研究专项课题(2018ZY2016)。
关键词
强直性脊柱炎
督灸
补肾祛寒化湿方
中医证候
血沉
C-反应蛋白
Ⅰ-型胶原蛋白C末端肽
Dickkopf1蛋白
Ankylosing spondylitis
Moxibustion at governor vessel
Bushen Quhan Huashi prescription
Chinese medicine syndrome
Erythrocyte sedimentation rate
C-reactive protein
C-terminal telopeptide of typeⅠcollagen
Dickkopf-1 protein
