摘要
目的:观察涤浊健脾通窍汤联合无创呼吸机治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的临床疗效。方法:将94例OSAHS患者随机分为治疗组与对照组各47例。2组均给予饮食及生活干预,对照组予无创呼吸机治疗,治疗组在此基础上内服涤浊健脾通窍汤,2组均连续治疗12周后判定疗效。比较2组患者治疗前后的中医证候积分、呼吸暂停低通气指数(AHI)、鼾声指数、最低血氧饱和度(LSpO_(2))、最长呼吸暂停时间、氧减指数(ODI)、Epworth嗜睡量表(ESS)评分、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-18(IL-18)及不良反应。结果:治疗组临床总有效率为91.49%,明显高于对照组的74.47%(P<0.05)。与同组治疗前比较,治疗后2组患者的中医证候积分、AHI、鼾声指数、最长呼吸暂停时间、ODI、ESS评分、CRP、TNF-α及IL-18均下降(P<0.05),LSpO_(2)均上升(P<0.05);与对照组治疗后比较,治疗组中医证候积分、AHI、鼾声指数、最长呼吸暂停时间、ODI、ESS评分、CRP、TNF-α及IL-18均较低(P<0.05),LSpO_(2)较高(P<0.05)。2组在治疗过程中均未出现严重不良反应。结论:涤浊健脾通窍汤联合无创呼吸机治疗痰瘀互结型OSAHS患者疗效显著,可有效改善患者AHI、鼾声指数、最长呼吸暂停时间、LSpO_(2)、ODI及ESS评分,降低炎症因子,减轻体内炎性反应。
Objective:To observe the clinical effect of Dizhuo Jianpi Tongqiao tang combined with bi-level positive airway pressure ventilator for obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods:A total of 94 cases of OSAHS patients were randomly divided into the treatment group and the control group,47 cases in each group.Both groups were given intervention of diet and life;the control group was additionally given bi-level positive airway pressure ventilator,and the treatment group was additionally given the oral administration of Dizhuo Jianpi Tongqiao tang based on the treatment of the control group.After 12-week continuous treatment,the curative effect was determined in the two groups.Chinese medicine syndrome scores,apnea-hypopnea index(AHI),snore index,the lowest pulse oxygen saturation(LSpO_(2)),the longest apnea duration,oxygen desaturation index(ODI),score of Epworth Sleepiness Scale(ESS),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-18(IL-18),and adverse reactions were compared in the two groups before and after treatment.Results:The total clinical effective rate was 91.49%in the treatment group,significantly higher than that of74.47%in the control group(P<0.05).When compared with those in the same group before treatment,Chinese medicine syndrome scores,AHI,snore index,the longest apnea duration,ODI,score of ESS,CRP,TNF-α,and IL-18 in the two groups were decreased after treatment(P<0.05),and LSpO_(2) was increased(P<0.05).After treatment,Chinese medicine syndrome scores,AHI,snore index,the longest apnea duration,ODI,score of ESS,CRP,TNF-α,and IL-18 in the treatment group were lower than those in the control group(P<0.05),and LSpO_(2) was higher(P<0.05).During treatment,no severe adverse reactions occurred in the two groups.Conclusion:The therapy of Dizhuo Jianpi Tongqiao tang combined with bi-level positive airway pressure ventilator has significant curative effect in the treatment of OSAHS patients of binding of phlegm and stasis type,which can effectively improve AHI,snore index,
作者
李瑞成
田秀芬
陶洁
LI Ruicheng;TIAN Xiufen;TAO Jie
出处
《新中医》
CAS
2021年第10期52-56,共5页
New Chinese Medicine
基金
河南省OSAHS患者数据库建立及应用(141PGJHZ547)。
关键词
阻塞性睡眠呼吸暂停低通气综合征
涤浊健脾通窍汤
无创呼吸机
痰瘀互结型
Obstructive sleep apnea-hypopnea syndrome
Dizhuo Jianpi Tongqiao tang
Bi-level positive airway pressure ventilator
Binding of phlegm and stasis type
