摘要
目的评估利奈唑胺对耐甲氧西林金黄色葡萄球菌(MRSA)高危易感人群院感防护的效果.方法选取2016年6月至2019年12月MRSA高危易感人群患者256例,随机分为A组与B组,各128例.A组:根据临床经验予相应抗感染方案,待病原学结果返回后再进一步调整抗感染方案,B组:确认存在MRSA高危因素后,予单间、专人管理,常规治疗基础上联合利奈唑胺0.6 g,1次/12 h抗感染,直至感染控制,评估MRSA检出率、炎症因子表达、病死率等.结果B组MRSA检出率、病死率均明显低于A组,差异有统计学意义(P<0.05);两组治疗后炎症因子表达水平明显降低(P<0.05);B组治疗后第3、5、7天后炎症因子表达降低比A组更明显(P<0.05).B组住院时间及住院费用明显低于A组(P<0.05).结论MRSA高危易感人群积极予利奈唑胺干预,能明显降低MRSA检出率及炎症因子表达水平,减少住院天数及住院费用,最终降低病死率,对于MRSA院感防控具有积极的意义,值得临床推荐.
Objective To evaluate the efet of linezolid on prevention and control of hospital infection against methicllin-rsisant Saphylococcus aureus(MRSA)in high-risk susceptible populations.Methods 256 patients with high risk susceptibility to MRSA from June 2016 to December 2019 were selected and randomly divided into group A and group B,with 128 patients in each group.Group A:the corresponding anti-infection scheme was given according to the clinical experience,and the anti-infection scheme was further adjusted after the etiological results were returned.Group B:After the high risk factors of MRSA were confirmed,the patients were administered in a single room or by special person.On the basis of conventional treatment,linezolid 0.6g was combined for anti-infection once every 12h until infection control.The detection rate of MRSA,the expression of inflammatory factors and the case fatality rate were evaluated.Results The detection rate and fatality rate of MRSA in group B were significantly lower than that in group A,and the differences were stistically significant(P<0.05).After treatment,the expression of inflammatory factors in both groups was significantly decreased(P<0.05).The decrease of inflammatory factors expression in group B was more obvious than that in group A at 3th,5th and 7th day after treatment(P<0.05).The length and cost of hospitalization in group B were significantly lower than those in group A(P<0.05)。Conclusion The active intervention of linezolid in high risk susceptible population of MRSA can significantly reduce the detection rate of MR SA and the expression level of inflammatory factors,reduce the length of hospital stay and hospitalization cost,and ulimately reduce the case fatality rate,which has a positive significance for the prevention and control of hospital infection of MRSA and is worthy of clinical recommendation.
出处
《浙江临床医学》
2021年第5期674-675,共2页
Zhejiang Clinical Medical Journal
基金
北京医卫健康公益基金会项目(T210)
浙江中医药大学校级课题项目(2018ZY27)。
