摘要
目的了解无锡地区医疗机构输血不良症状发生情况,为进一步提升本地区输血安全提供理论依据。方法收集无锡地区医疗机构2017~2019年211 778例输血病例,并对输血不良症状进行回顾性分析。结果近3年无锡地区共发生输血不良症状750例,发生率为0.35%(750/211 778),呈逐年上升趋势。其中输注单采血小板不良反应率最高,约0.86%(占比32.8%,246/750),病毒灭活冰冻血浆为0.1%(占比30.4%,228/750),均呈逐年上升趋势;去白悬浮红细胞为0.12%(257/220 106),洗涤红细胞0.08%(5/6 439),两者占比34.9%(262/750);冷沉淀0.02%(占比1.9%,14/750)。不良反应类型主要为过敏反应(约占67.6%,507/750)和发热反应(28.8%,216/750),两者发生率亦呈逐年递增趋势;另外还包括输血相关循环过载6例(0.8%,6/750),输血后紫癜2例(0.27%,2/750),输血相关急性肺损伤1例(0.13%,1/750)及其它18例(2.4%,18/750)。进一步分析发现引起发热反应的主要为红细胞类成分血,引起过敏反应的主要为血小板及血浆类成分血。结论本地区输血不良症状率低于国内一般水平,但有逐年上升的趋势,主要由输注冷沉淀外的成分血引起的过敏和发热反应构成,同时各医疗机构应采取措施加强输血不良症状监控力度,在确保上报准确及时的基础上,采取综合措施对输血不良症状进行预防和控制,进一步降低其发生率。
Objective To explore the incidence of adverse reactions to blood transfusion in Wuxi, so as to provide theoretical basis for further improving the safety of blood transfusion in this area. Methods 211 778 cases of blood transfusion in hospitals in Wuxi from 2017 to 2019 were collected, and the incidence of adverse reactions were retrospectively analyzed. Results From 2017 to 2019, 750 cases of adverse reactions occurred in Wuxi, with the incidence rate at 0.35%(750/211 778), which kept increasing year by year. The incidence of reactions relative to apheresis platelet transfusion was the highest, about 0.86%(accounting for 32.8%,246/750), viral inactivated frozen plasma transfusion 0.1%(accounting for 30.4%,228/750), showing an increasing trend year by year, suspension of leukocytes reduced RBC 0.12%(257/220 106), washed RBC 0.08%(5/6 439) and cryoprecipitate 0.02%(14/750) respectively(the above three accounting for 36.8%,216/750). The adverse reactions were mainly allergic reactions(67.6%,507/750) and febrile non-haemolytic transfusion reaction(FNHTR)(28.8%,216/750), and the incidence of both increased year by year. In addition, there were 6 cases(0.8%,6/750) of transfusion-associated circulation overload, 2 cases(0.27%,2/750) of post transfusion purpura, 1 case(0.13%,1/750) of transfusion-related acute lung injury and 18 miscellaneous cases(2.4%,18/750). Further analysis revealed that red blood cell products were the main causes for FNHTR, and platelets and plasma products for allergic reactions. Conclusion The incidence of adverse reactions in Wuxi, mainly composed of allergic and febrile reactions caused by transfusions of blood components other than cryoprecipitate, was lower than the general level in China, but it kept increasing year by year. Measures should be taken by hospitals to strengthen the monitoring, reporting of adverse reactions, so as to prevent and further reduce the incidence of adverse reactions.
作者
华敏玉
郝庆钦
夏卫
HUA Minyu;HAO Qingqin;XIA Wei(Wuxi Red Cross Blood Center,Wuxi Quality Control Center of Transfusion,TTzzxi 214021,China)
出处
《中国输血杂志》
CAS
2021年第5期498-501,共4页
Chinese Journal of Blood Transfusion
关键词
输血不良症状
过敏反应
非溶血性发热反应
血小板
adverse reactions to blood transfusion
allergic reaction
febrile non-hemolytic reaction
platelet
