摘要
目的观察图像引导放疗对支气管阻塞性非小细胞肺癌患者疾病控制的作用。方法选取2017年10月—2018年10月石家庄市人民医院肿瘤科四病区收治的支气管阻塞性非小细胞肺癌患者100例作为研究对象,根据随机数字表法分为对照组(n=50)和试验组(n=50)。对照组给予调强放疗,试验组给予图像引导放疗。观察2组治疗2个月后短期疗效、疾病控制率,治疗前后支气管狭窄(气促指数、支气管内径)、肺功能(FEV1占预计值百分比、FVC占预计值百分比)变化,记录急性放射性损伤发生情况,比较治疗后1年生存率。结果试验组治疗总有效率、疾病控制率均略高于对照组(68.00%vs.60.00%,96.00%vs.90.00%),但差异无统计学意义(P>0.05);治疗后,2组气促指数低于治疗前,支气管内径、FEV1占预计值百分比、FVC占预计值百分比均高于治疗前,且试验组改善较对照组更显著,差异均有统计学意义(t/P=2.586/0.011、2.980/0.004、3.782/0.000、3.686/0.000);试验组急性放射性肺损伤、急性放射性食管炎及急性骨髓抑制程度Ⅱ~Ⅲ级低于对照组(χ2/P=4.320/0.038、6.353/0.012、4.000/0.046);对照组治疗后1年内生存率低于试验组(18.00%vs.26.00%,χ2/P=8.787/0.003)。结论图像引导放疗可在有效控制支气管阻塞性非小细胞肺癌患者病情发展同时,减少放射性损伤,改善患者支气管狭窄及肺功能情况,且可一定程度上延长患者生存时间。
Objective To observe the effect of image-guided radiotherapy on disease control in patients with bronchial obstructive non-small cell lung cancer.Methods From October 2017 to October 2018,100 patients with bronchial obstructive non-small cell lung cancer admitted to the fourth ward of the Oncology Department of Shijiazhuang People’s Hospital were selected as the research objects.According to the random number table method,they were divided into control groups(n=50)and Experimental group(n=50).The control group was given intensity-modulated radiotherapy,and the test group was given image-guided radiotherapy.Observe the short-term curative effect,disease control rate,bronchial stenosis(shortness of breath index,bronchial inner diameter),lung function(FEV1 as a percentage of predicted value,FVC as a percentage of predicted value)before and after treatment in the two groups after 2 months of treatment.Record the occurrence of acute radiation injury,compare the survival rate within 1 year after treatment.Results The total effective rate and disease control rate of the experimental group were slightly higher than those of the control group(68.00%vs.60.00%,96.00%vs.90.00%),but the difference was not statistically significant(P>0.05);after treatment,the 2 groups were short of breath The index is lower than before treatment,bronchus inner diameter,FEV1 as a percentage of predicted value,and FVC as a percentage of predicted value are all higher than before treatment,and the improvement of the experimental group is more significant than that of the control group,and the difference is statistically significant(t/P=2.586/0.011,2.980/0.004,3.782/0.000,3.686/0.000);the degree of acute radiation lung injury,acute radiation esophagitis and acute bone marrow suppression in the experimental group was lower than the control group(χ2/P=4.320/0.038,6.353/0.012,4.000/0.046);the survival rate of the control group within 1 year after treatment was lower than that of the test group(18.00%vs.26.00%,χ2/P=8.787/0.003).Conclusion Image-gu
作者
赵新
韩鲁军
张淼
张燕
许会军
陈晓芳
马骖
Zhao Xin;Han Lujun;Zhang Miao;Zhang Yan;Xu Huijun;Chen Xiaofang;Ma Cheng(The Fourth Department of Oncology,People’s Hospital of Shijiazhuang City,Hebei Province,Shijiazhuang 050000,China)
出处
《疑难病杂志》
CAS
2021年第6期574-578,共5页
Chinese Journal of Difficult and Complicated Cases
基金
河北省重点研发计划自筹项目(172777135)。
关键词
非小细胞肺癌
支气管阻塞
图像引导放疗
疾病控制
Non-small cell lung cancer
Bronchial obstruction
Image-guided radiotherapy
Disease control
