摘要
背景原发性腹膜后肿瘤多为恶性肿瘤,其病因多种多样.分级、切除范围和肿瘤完整性等参数已被证明影响预后.目的探索影响原发性腹膜后肿瘤手术患者术后生存的危险因素.方法73例腹膜后肿瘤根治性手术的患者分为无瘤生存组(47例)、复发死亡组(26例).收集并分析影响患者术后无瘤生存的因素,包括年龄、肿瘤长径、淋巴结转移、首发症状、肿瘤类型、肿瘤分化程度以及是否合并其他系统疾病等.结果原发性腹膜后肿瘤术后5年无瘤生存率为64.4%(47/73).对影响原发性腹膜后肿瘤术后无瘤生存率的因素进行单因素分析结果显示:年龄(P<0.05),肿瘤长径(P<0.05),淋巴结转移(P<0.05),首发症状(P<0.05),肿瘤类型(P<0.05),肿瘤分化程度(P<0.05)共6项因素与腹膜后肿瘤术后无瘤生存率相关.多因素Cox回归分析结果提示首发症状(P<0.05)以及肿瘤类型(P<0.05)影响腹膜后肿瘤患者术后无瘤生存率的独立危险因素.结论首发症状以及肿瘤类型是影响腹膜后肿瘤患者术后无瘤生存率的关键.
BACKGROUND Primary retroperitoneal tumors are mostly malignancies with a variety of etiologies.Parameters such as tumor grade,range of resection,and tumor integrity have been shown to influence prognosis.AIM To identify the risk factors for postoperative survival in patients undergoing primary retroperitoneal tumor surgery.METHODS Seventy-three patients undergoing radical retroperitoneal tumor surgery were divided into a tumor-free survival group(47 cases)and a recurrence-caused death group(26 cases).Factors affecting patients’tumor-free survival after surgery were collected and analyzed,including age,tumor long diameter,lymph node metastasis,first symptom,tumor type,tumor differentiation degree,and complication with other systemic diseases.RESULTS The 5-year tumor-free survival rate for primary retro-peritoneal tumors was 64.4%(47/73).Single factor analysis showed that age(P<0.05),tumor long diameter(P<0.05),lymph node metastasis(P<0.05),first symptom(P<0.05),tumor type(P<0.05),and tumor differentiation degree(P<0.05)were significantly associated with retroperitoneal tumor surgery disease-free survival rate.Multivariate Cox regression analysis indicated that first symptom(P<0.05)and tumor type(P<0.05)were independent risk factors affecting postoperative tumor-free survival in retroperitoneal tumor patients.CONCLUSION First symptom and tumor type are the key factors affecting the postoperative tumor-free survival of retroperitoneal tumor patients.
作者
郭丽娜
李云超
孙占峰
闫海洋
李辉
王月明
Li-Na Guo;Yun-Chao Li;Zhan-Feng Sun;Hai-Yang Yan;Hui Li;Yue-Ming Wang(Department of Hepatobiliary and Pancreatic Surgery,Second Hospital of Tianjin Medical University,Tianjin 300211,China;Department of General Surgery,Tianjin Ninghe District Hospital,Tianjin 301500,China;Rescue Research Institute of Affiliated Hospital of Logistical College of Armed Police,Tianjin 300162,China)
出处
《世界华人消化杂志》
CAS
2021年第9期461-466,共6页
World Chinese Journal of Digestology
基金
天津市科技支撑计划项目,No.15ZXLCSY00040
武警后勤学院基础研究项目,No.WHJ201721.
关键词
原发性腹膜后肿瘤
预后
生存率
危险因素
首发症状
肿瘤分化
Primary retroperitoneal tumor
Prognosis
Survival rates
Risk factors
First symptoms
Tumor differentiation
