摘要
背景目前的肝细胞癌(hepatocellular carcinoma,HCC)分期系统对肝癌手术切除后患者预后判断并不理想,早期发现和识别这些术后易复发的患者并进行针对性干预至关重要.近年来肝脏免疫与疾病的关系成为研究热点,白细胞介素(interleukin,IL)-26可预测HCC患者的预后,但对于接受HCC手术切除患者的术后5年预后情况尚缺乏研究.目的分析乙肝相关HCC患者肝癌组织中IL-26对接受肿瘤切除治疗患者的预后判断价值.方法收集2006-01/2015-06期间在我院住院并手术治疗的乙肝相关HCC患者术前资料.免疫组化测量切除肝癌组织中IL-26的表达量,并根据测得全部肝癌组织IL-26水平中位数分为IL-26高表达组和IL-26低表达组.Kaplan-Meier法比较两组患者5年的总生存期(overall survival,OS)和无进展生存期(progression free survival,PFS).结果共纳入131例患者,IL-26高表达组患者的肿瘤>5cm(P=0.026)、微血管侵犯(P=0.009)、TNM分期Ⅲ-Ⅳ期(P=0.045)明显多于IL-26低表达组.IL-26高表达(HR=1.667,P=0.022)、肿瘤>5 cm(HR=1.096,P=0.002)、微血管侵犯(HR=2.696,P=0.006)是HCC切除患者PFS的影响因素.IL-26高表达(HR=1.643,P=0.041)和微血管侵犯(HR=3.303,P=0.016)是HCC切除患者的OS的独立预后因素.IL-26高表达组患者的PFS、OS较IL-26低表达组差(P<0.05).结论肝癌组织中IL-26表达量与乙肝相关肝癌患者切除术后的生存期和无进展生存期存在相关性.
BACKGROUND The current hepatocellular carcinoma(HCC)staging system is not ideal for judging the prognosis of patients after surgical resection,so it is very important to find and identify the patients who are prone to recurrence and carry out targeted intervention.In recent years,the relationship between liver immunity and HCC has become a research hotspot.Interleukin(IL)-26 can predict the prognosis of patients with HCC,but there is a lack of research on the prognosis of patients 5 years after surgery.AIM To analyze the prognostic value of IL-26 in HCC tissues of patients with hepatitis B.METHODS The preoperative data of hepatitis B related HCC patients who were hospitalized and operated at our hospital from January 2006 to June 2015 were collected.The expression of IL-26 in resected HCC tissues was measured by immunohistochemistry and based on the median expression level of IL-26,the patients were divided into either a high expression group or a low expression group.The 5-year overall survival(OS)and progression free survival(PFS)were compared between the two groups by Kaplan-Meier method.RESULTS The percentages of patients with a tumor size>5 cm,microvascular invasion,and TNM stage III/IV disease in the high expression group were significantly higher than those of the low expression group(P=0.026,0.009,and P=0.045,respectively).High expression of IL-26(hazard ratio[HR]=1.667,P=0.022),tumor size>5 cm(HR=1.096,P=0.002),and microvascular invasion(HR=2.696,P=0.006)were the influencing factors of PFS in patients with HCC resection.High expression of IL-26(HR=1.643,P=0.041)and microvascular invasion(HR=3.303,P=0.016)were independent prognostic factors for OS in patients with HCC resection.PFS and OS in patients with high expression of IL-26 were worse than those with low expression.CONCLUSION The expression of IL-26 in HCC tissue correlates with the OS and PFS of patients with hepatitis B-related liver cancer after resection.
作者
鲍建亨
尚海涛
郝成飞
刘军舰
韩树旺
张德林
李忠廉
Jian-Heng Bao;Hai-Tao Shang;Cheng-Fei Hao;Jun-Jian Liu;Shu-Wang Han;De-Lin Zhang;Zhong-Lian Li(Second Department of Hepatobiliary and Pancreatic Surgery,Nankai Hospital,Tianjin 300100,China)
出处
《世界华人消化杂志》
CAS
2021年第10期511-516,共6页
World Chinese Journal of Digestology
基金
天津市卫生健康委员会中医药重点领域科研项目,No.2019003.
