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唑来膦酸注射液联合降钙素治疗75例老年骨质疏松患者的疗效及对血清IL-6、TNF-α水平的影响 被引量:5

Efficacy of zoledronic acid injection combined with calcitonin in the treatment of 75 elderly patients with osteoporosis and its effect on serum IL-6 and TNF-αlevels
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摘要 目的探讨唑来膦酸注射液联合降钙素治疗老年骨质疏松患者的临床疗效及其对血清IL-6、TNF-α水平的影响。方法选取2018年1月至2019年1月我院收治的149例患者,将其随机分为观察组(n=75)和对照组(n=74)。对照组采用降钙素治疗,观察组在此基础上联合唑来膦酸注射液治疗。观察比较两组临床疗效、腰椎密度、VAS评分及血清IL-6、TNF-α水平。结果观察组显效48例(64.00%)、有效22例(29.33%)、无效5例(6.67%),整体临床疗效优于对照组,差异有统计学意义(P<0.05);观察组临床有效率为93.33%,明显高于对照组的75.68%,差异有统计学意义(P<0.05)。治疗后,两组腰椎密度较治疗前升高,腰背部VAS评分较治疗前降低,差异有统计学意义(P<0.05);且与对照组相比,观察组腰椎密度明显升高、腰背部VAS评分明显降低,差异有统计学意义(P<0.05)。治疗后两组IL-6、TNF-α水平较治疗前明显下降,差异有统计学意义(P<0.05),且观察组IL-6、TNF-α水平均显著低于对照组,差异有统计学意义(P<0.05)。结论唑来膦酸注射液联合降钙素治疗对老年骨质疏松临床疗效显著,可有效改善患者骨痛症状,增加骨量,提高骨密度,降低炎症因子水平,值得推广应用。 Objective To investigate the clinical efficacy of zoledronic acid injection combined with calcitonin in the treatment of elderly patients with osteoporosis and its effect on serum IL-6 and TNF-αlevels.Methods A total of 149 patients admitted to our hospital from January 2018 to January 2019 were selected and randomly divided into the observation group(n=75)and the control group(n=74).The control group was treated with calcitonin,and the observation group was treated with zoledronic acid injection on this basis.The clinical efficacy,lumbar bone mineral density,VAS score,and serum IL-6 and TNF-αlevels between the two groups were observed and compared.Results In the observation group,48 cases were markedly effective(64.00%),22 cases were effective(29.33%),and 5 cases were ineffective(6.67%).The overall clinical efficacy in the observation group was better than that in the control group,with significant difference(P<0.05).The clinical effect rate in the observation group was 93.33%,which was significantly higher than that in the control group(75.68%),with significant difference(P<0.05).After treatment,the density of the lumbar spine between the two groups increased more obviously than that before treatment,and the VAS score of the lumber and back decreased more obviously than that before treatment,with significant difference(P<0.05).Compared with the control group,the density of the lumbar spine in the observation group was higher than that in the control group,and the VAS score of the lumber and back in the observation group was lower than that in the control group,with significant difference(P<0.05).After the treatment,the levels of IL-6 and TNF-αbetween the two groups decreased more obviously than those before the treatment,with significant difference(P<0.05),and the levels of IL-6 and TNF-αin the observation group were significantly lower than those in the control group,with significant difference(P<0.05).Conclusion Zoledronic acid injection combined with calcitonin has a significant clinical effect on elderl
作者 高艳红 哈海枫 陈小军 蔡艳丽 GAO Yanhong;HA Haifeng;CHEN Xiaojun;CAI Yanli(Department of Endocrinology,Qinghai Traffic Hospital,Xi′ning 810000,China)
出处 《中国现代医生》 2021年第13期42-45,共4页 China Modern Doctor
关键词 唑来膦酸 降钙素 老年骨质疏松 骨密度 IL-6 Zoledronic acid Calcitonin Senile osteoporosis Bone density IL-6
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