摘要
目的分析有血流动力学意义的动脉导管未闭(hsPDA)早产儿的危险因素。方法选择2018年1月—2020年6月安徽省宣城市人民医院(以下简称“我院”)新生儿科住院的80例hsPDA早产儿作为观察组,并选择我院儿科同期分娩的无hsPDA早产儿80例作为对照组。比较两组早产儿出生后24 h内血小板计数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)、血小板压积(PCT)、大血小板比率(P-LCR);hsPDA早产儿危险因素分析采用logistic回归分析。结果两组早产儿胎龄、出生体重、新生儿1 min Apgar评分、新生儿呼吸窘迫综合症、动脉导管直径、左房内径/主动脉内径比较,差异均有高度统计学意义(均P<0.01)。两组产妇剖宫产、妊娠期高血压占比比较,差异均有统计学意义(均P<0.05)。两组早产儿PLT、P-CLR比较,差异无统计学意义(P>0.05);观察组MPV、PDW、PCT低于对照组,差异均有高度统计学意义(均P<0.01)。logistic回归分析结果显示,胎龄(OR=0.721,95%CI:0.270~0.932)、剖宫产(OR=0.601,95%CI:0.168~0.970)、妊娠期高血压(OR=0.699,95%CI:0.231~0.807)、MPV(OR=1.669,95%CI:1.217~2.288)、PDW(OR=1.906,95%CI:1.460~2.488)和PCT(OR=1.636,95%CI:1.243~2.152)是早产儿发生hsPDA的影响因素(P<0.05)。结论在hsPDA早产儿中,MPV、PDW和PCT表达明显降低,且胎龄、剖宫产、妊娠期高血压、MPV、PDW和PCT均是导致疾病发生的独立危险因素,临床应用价值高。
Objective To analyze the risk factors of patent ductus arteriosus with hemodynamic significance(hsPDA)in premature infants.Methods From January 2018 to June 2020,80 cases of preterm infants with hsPDA admitted to Department of Neonatology,Xuancheng People’s Hospital,Anhui Province(“our hospital”for short)were selected as the observation group,and 80 cases of preterm infants without hsPDA delivered in our hospital during the same period were selected as the control group.The platelet(PLT)count,mean platelet volume(MPV),platelet distribution width(PDW),platelet hematocrit(PCT)and platelet large cell ratio(P-LCR)were compared between the two groups within 24 hours after birth;risk factors of hsPDA preterm infants were analyzed by logistic regression analysis.Results There were highly significant differences in gestational age,birth weight,neonatal 1 min Apgar score,neonatal respiratory distress syndrome,arterial duct diameter,left atrial diameter/aortic diameter between the two groups(all P<0.01).There were significance differences in the ratio of cesarean section and gestational hypertension between the two groups(all P<0.05).There were no significant differences in PLT and P-LCR between the two groups(P>0.05);MPV,PDW and PCT in the observation group were lower than those in the control group,and the differences were highly statistically significant(all P<0.01).Logistic regression analysis results showed that gestational age(OR=0.721,95%CI:0.270-0.932),cesarean section(OR=0.601,95%CI:0.168-0.970),gestational hypertension(OR=0.699,95%CI:0.231-0.807),MPV(OR=1.669,95%CI:1.217-2.288),PDW(OR=1.906,95%CI:1.460-2.488)and PCT(OR=1.636,95%CI:1.243-2.152)were influnce factors of hsPDA in preterm infants(P<0.05).Conclusion In preterm infants with hsPDA,the expression of MPV,PDW and PCT are significantly reduced,the gestational age,cesarean section,gestational hypertension,MPV,PDW and PCT are independent risk factors for the disease,and have high clinical application value.
作者
万元
李亚林
汪丹丹
WAN Yuan;LI Yalin;WANG Dandan(Department of Neonatology,Xuancheng People’s Hospital,Anhui Province,Xuancheng 242000,China)
出处
《中国医药导报》
CAS
2021年第14期85-88,共4页
China Medical Herald
关键词
早产儿
动脉导管未闭
血小板参数
临床意义
影响因素
Preterm infants
Patent ductus arteriosus
Platelet parameters
Clinical significance
Influnce factors
