摘要
在帕金森病状态下,中枢神经系统内存在的大量异常神经电活动,其扰乱了正常的生理性电活动,导致一系列相关症状的产生。其中基底神经节内丘脑底核的异常神经电活动在帕金森病的发生中起着重要作用,其核团内放电频率、放电模式、电振荡活动、内部网络结构的改变与帕金森病的运动症状及非运动症状的出现有着紧密的联系,而各种异常电活动的产生又有着各自不同的病理机制。该文对帕金森病状态下丘脑底核异常神经电活动、相关症状及形成机制中的研究进展作一综述。
In the context of Parkinson’s disease,there are a large number of abnormal neuroelectric activities in the central nervous system,which disrupt normal physiological electrical activities,causing a series of related symptoms.Among them,the abnormal neuroelectric activities of the subthalamic nucleus in the basal ganglia play an important role in Parkinson’s disease.The firing frequency,firing pattern,electrical oscillation activity,and the changes in the internal network structure in the nucleus are closely related to the motor and non-motor symptoms in Parkinson’s disease.Various abnormal electrical activities have their respective pathological mechanisms.This article reviews the research progress in abnormal neuroelectric activities of the subthalamic nucleus in the context of Parkinson’s disease,the related symptoms,and formation mechanism.
作者
程驰
徐岩
曹学兵
CHENG Chi;XU Yan;CAO Xue-Bing(Department of Neurology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wu-han,Hubei 430022,China)
出处
《国际神经病学神经外科学杂志》
2021年第2期176-180,共5页
Journal of International Neurology and Neurosurgery
关键词
帕金森病
丘脑底核
电生理
机制
Parkinson’s disease
subthalamic nucleus
electrophysiology
mechanism
