摘要
目的探讨艰难梭状芽胞杆菌感染的高危易感因素,为提高艰难梭状芽胞杆菌感染评估能力提供参考依据。方法选取2018年5月至2020年3月于四川大学华西医院住院接受治疗的296例患者为研究对象,其中临床表现为腹泻且粪便中艰难梭状芽胞杆菌阳性的134例住院患者作为感染组;同期明确为无艰难梭状芽胞杆菌感染的住院患者162例作为对照组。收集整理两组一般资料;采用全自动生化分析仪检测两组肌酐、丙氨酸氨基转移酶、白蛋白水平,全自动血液分析仪检测两组白细胞计数;采用单因素和多因素logistic回归分析影响患者艰难梭状芽胞杆菌感染的因素。结果感染组白细胞计数、发热、非酒精性脂肪性肝病、呼吸系统疾病、心血管疾病、胃肠道疾病、恶性肿瘤、重症监护病史、药物治疗情况(包括化疗、喹诺酮类使用、碳青霉烯类使用、胃酸抑制剂使用、头孢菌素)使用比例高于对照组,白蛋白水平低于对照组,差异均有统计学意义(P<0.05);多因素logistic回归分析结果显示,非酒精性脂肪性肝病、使用喹诺酮类药物是影响艰难梭状芽胞杆菌感染的独立危险因素(P<0.05)。结论非酒精性脂肪性肝病、使用喹诺酮类药物是艰难梭状芽胞杆菌感染的易感因素,对于临床预防艰难梭状芽胞杆菌感染可能有较高的参考价值。
Objective To explore the high risk factors of Clostridium difficile,and to provide reference for improving the ability to evaluate the Clostridium difficile infection.Methods A total of 296 patients who were hospitalized in West China Hospital of Sichuan University from May 2018 to March 2020 were selected as the study objects,among whom 134 patients with diarrhea and positive fecal Clostridium difficile were selected as the infection group;at the same time,162 hospitalized patients without Clostridium difficile infection were selected as the control group.The general clinical data of patients were collected and sorted out;the levels of creatinine,alanine aminotransferase and albumin were measured by automatic biochemical analyzer,andthe leukocyte count was detected by automatic blood analyzer.In addition,single factor and multi factor Logistic regression analyses were used to analyze the factors influencing the infection of Clostridium difficile.Results There was no significant difference between the two groups in gender,age,residence,serum creatinine,alanine aminotransferase,chronic kidney disease,blood disease and metabolic disease(P>0.05);theleukocyte count,proportions of fever,non-alcoholic fatty liver disease,respiratory system disease,cardiovascular disease,gastrointestinal disease,malignant tumor,history of intensive care,chemotherapy,quinolones use,carbapenems use,gastric acid inhibitor use,cephalosporin use in infection group were higher than those in control group,the level of albumin was lower than that in control group,and the differences were all statistically significant(P<0.05);single factor Logistic regression analysis showed that fever,nonalcoholic fatty liver disease,cardiovascular disease and quinolones were the risk factors of Clostridium difficile infection(P<0.05);in addition,multivariate Logistic regression analysis showed that nonalcoholic fatty liver disease and quinolones were the independent risk factors of Clostridium difficile infection(P<0.05).Conclusions Nonalcoholic fatty liver di
作者
王明娇
陈娟
陈丽
WANG Mingjiao;CHEN Juan;CHEN Li(Department of Clinical Laboratory,West China Hospital of Sichuan University,Chengdu 611135,China)
出处
《安徽医学》
2021年第5期544-548,共5页
Anhui Medical Journal
