摘要
目的:探究大剂量甲基泼尼松龙冲击联合神经节苷脂治疗对急性脊髓炎患者炎症反应、免疫平衡的影响。方法:选取2019年1月-2020年6月108例急性脊髓炎患者作为研究对象,随机分为联合疗法组和常规疗法组各54例,常规疗法组采用大剂量甲基泼尼松龙冲击治疗,联合疗法组采用大剂量甲基泼尼松龙冲击联合神经节苷脂进行治疗。治疗27 d后进行各项指标及疗效评价。结果:常规疗法组治疗总有效率为72.22%,远低于联合疗法组的88.89%(P<0.05)。治疗后,两组CRP、IL-6、TNF-α三项炎性指标均呈现显著下降趋势(P<0.05),最终联合疗法组三项指标水平明显低于常规疗法组(P<0.05)。通过治疗,两组CD3^(+)CD4^(+)CD25^(+)Treg均上升,CD3^(+)CD8^(+)IL-17ATh17、Th17/Treg均下降,最终联合疗法组Th17/Treg水平显著低于常规疗法组(P<0.05)。治疗期间,联合疗法组不良反应总发生率为11.11%,高于常规疗法组的7.40%,但差异无统计学意义(P>0.05)。结论:大剂量的甲基泼尼松龙联合神经节苷脂运用于急性脊髓炎的治疗具有较好的临床效果,能有效改善患者炎症反应及免疫平衡状态,具有较高的安全性,值得临床推广。
Objective:To explore the effect of high dose Methylprednisolone combined with Ganglioside on inflammatory response and immune balance in patients with acute myelitis.Method:A total of 108 patients with acute myelitis from January 2019 to June 2020 were randomly divided into the combined therapy group and the conventional therapy group.The conventional therapy group was treated with high-dose Methylprednisolone,and the combined therapy group was treated with high-dose Methylprednisolone and Ganglioside.After 27 days of treatment,all indexes and curative effect were evaluated.Result:The total effective rate of conventional therapy group was 72.22%,far lower than 88.89%of combined therapy group(P<0.05).After treatment,the three inflammatory indexes of CRP,IL-6 and TNF-αin the two groups showed a significant downward trend(P<0.05),and the level of the three indexes in the combined therapy group were significantly lower than those in the conventional therapy group(P<0.05).After treatment,CD3^(+)CD4^(+)CD25^(+)Treg increased,CD3^(+)CD8^(+)IL-17ATh17 and Th17/Treg decreased in both groups.Finally,Th17/Treg level in the combined therapy group was significantly lower than that in the conventional therapy group(P<0.05).During the treatment,the total incidence of adverse reactions in the combined therapy group was 11.11%,which was higher than that in the conventional therapy group(7.40%),but there was no significant difference(P>0.05).Conclusion:High-dose Methylprednisolone combined with Ganglioside in the treatment of acute myelitis has a good clinical effect,can effectively improve the inflammatory response and immune balance of patients.This therapy method has a high safety,and is worth clinical promotion.
作者
郭辉
GUO Hui(Jingzhou Second People’s Hospital,Jingzhou 434000,China)
出处
《中外医学研究》
2021年第14期61-64,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
