摘要
目的以2,4-己二炔-1,6-二烷基脲为原料制备疫苗温度标签,并对其重结晶和共结晶的制备,以及显色动力学规律进行研究,为疫苗温度标签的商业化应用提供理论指导。方法通过使用不同溶剂对2,4-己二炔-1,6-二乙基脲的重结晶,以及不同比例的2,4-己二炔-1,6-二乙基脲和2,4-己二炔-1,6-二丙基脲的共结晶进行实验,确定最适宜的配方,并对其显色动力学规律进行研究,利用分光密度仪对光密度值进行测定,进而通过计算得到反应活化能。结果不同溶解度的溶剂重结晶2,4-己二炔-1,6-二乙基脲后的固相聚合反应速率不同,通过实验发现以m乙醇∶m水=3∶1的混合溶液为溶剂重结晶,以及mKE∶mKPR=2∶1共结晶得到的产物热反应性较好,颜色变化较为鲜明,且通过计算得到该固相聚合反应的活化能为31.94 kJ/mol。结论将2,4-己二炔-1,6-二烷基脲作为新型的化学型疫苗温度标签,其视觉响应信号易于识别;通过重结晶和共结晶的改性来匹配不同种类的疫苗,可直观反映疫苗在冷链运输、保存和使用环节的质量。
The re-crystallization of 2,4-hexadiyn-1,6-dialkylurea,the preparation of co-crystallization and its color development kinetics were studied,which provided theoretical guidance for the commercial application of Vaccine vial monitor.Through the re-crystallization of 2,4-hexadiyn1,6-diethylurea with different solvents and the co-crystallization test of 2,4-hexadiyn-1,6-bis(ethylurea)(KE)and 2,4-hexadiyn-1,6-bis(propylurea)(KPr)with different proportions,the most suitable formula was determined,and its color development kinetics was studied.The optical density was meas-ured by spectrophotometer.The results showed that the solid-state polymerization reaction rates of recrystallizing 2,4-hexadiyne-1,6-bis(ethylurea)with different solubility solvents were different.Through experiments,it is found that the product obtained by recrystallization with the mixed solution of methanol∶mwater=3∶1 and cocrystallization at mKE∶mKPR=2∶1 has better thermal reactivity and distinct color change,and the activation energy of the solid-state polymeri-zation reaction is calculated to be 31.94 kJ/mol.2,4-hexadiyn-1,6-dialkylurea is a new chemical time and temperature indicator,and its visual response signal is easy to recognize.Matching different kinds of vaccines by re-crystallization and modification of co-crystallization can directly reflect the quality of vaccines in cold chain transportation,preserva-tion and use.
作者
张嘉帅
钱静
俞胡斐
崔小波
ZHANG Jia-shuai;QIAN Jing;YU Hu-fei;CUI Xiao-bo(School of Mechanical Engineering,Jiangnan University,Wuxi 214122,China;Jiangsu Zheqin Technology Co.,Ltd.,Wuxi 214001,China)
出处
《包装工程》
CAS
北大核心
2021年第11期60-66,共7页
Packaging Engineering
基金
国家重点研发计划(2018YFC1603300)
无锡科技局产业前瞻与关键技术(现代农业)(N20193008)。
关键词
疫苗温度标签
2
4-己二炔-1
6-二烷基脲
重结晶
共结晶
活化能
vaccine vial monitor
2,4-hexadiyn-1,6-dialkylurea
re-crystallization
co-crystallization
activation energy
