摘要
目的评价ABO溶血病新生儿的血清学检测及临床意义。方法88例ABO溶血病新生儿为研究对象,按照ABO溶血三项检查结果分为A组[直接抗球蛋白抗体、游离抗体、抗体释放(+),10例];B组[游离抗体、直接抗球蛋白抗体(+),16例];C组[直接抗球蛋白抗体、抗体释放(+),16例]和D组[抗体释放(+),46例]。四组患儿均给予常规治疗及大剂量免疫球蛋白治疗。检测并比较四组患儿治疗前后血清总胆红素水平。结果治疗前,B组患儿的血清总胆红素为(364.38±52.63)μmol/L,C组患儿的血清总胆红素为(371.25±25.36)μmol/L,D组患儿的血清总胆红素为(382.63±56.68)μmol/L,均高于A组的(319.36±52.36)μmol/L,差异具有统计学意义(P<0.05)。治疗后,四组患儿血清总胆红素水平均低于治疗前,差异具有统计学意义;但四组治疗后血清总胆红素水平对比,差异无统计学意义(P>0.05)。结论为ABO溶血病新生儿进行血清学检测,能够了解其血清总胆红素水平变化情况,对评估新生儿治疗效果有所帮助,所以可推广该方法。
Objective To evaluate the serological detection of ABO hemolytic disease in newborns and its clinical significance.Methods A total of 88 newborns with ABO hemolytic disease as study subjects were divided into group A[direct antiglobulin antibody,free antibody,antibody release(+),10 cases],group B[free antibody,direct anti-globulin antibody(+),16 cases],group C[direct anti-globulin antibody,antibody release(+),16 cases]and group D[antibody release(+),46 cases]according to the results of ABO hemolysis.All four groups received conventional treatment and high-dose immunoglobulin therapy.The serum total bilirubin levels of the four groups before and after treatment were compared.Results Before treatment,the serum total bilirubin of group B,group C,group D were(364.38±52.63),(371.25±25.36),(382.63±56.68)μmol/L,which were higher than(319.36±52.36)μmol/L of group A,and the difference was statistically significant(P<0.05).After treatment of serum total bilirubin of the four groups was lower than those before treatment,and the difference was statistically significant(P<0.05).But there was no statistically significant difference in serum total bilirubin of the four groups after treatment(P>0.05).Conclusion Serological detection for ABO hemolytic disease newborns can understand the changes of serum total bilirubin,which is helpful to evaluate the treatment effect of newborns,so this method can be popularized.
作者
邓妮君
钟婉婷
钟敏仙
DENG Nijun;ZHONG Wan-ting;ZHONG Min-xian(Laboratory Medicine Center,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,China)
出处
《中国实用医药》
2021年第15期69-71,共3页
China Practical Medicine
关键词
ABO溶血病
新生儿血清学检测
血清总胆红素
ABO hemolytic disease
Neonatal serological detection
Serum total bilirubin
