摘要
动脉粥样硬化性心血管疾病(ASCVD)是包括急性冠脉综合征、心肌梗死史、稳定或不稳定型心绞痛、冠状动脉或其他血管重建术、缺血性卒中、短暂性脑缺血发作和周围血管病变等的一类疾病,其在老年患者中的高发病率、高致残率、高病死率给患者家庭及社会带来了沉重的负担,但其早期预警指标仍处于探索阶段。肌少症是一种老年人的常见疾病,大量研究发现,肌少症可能是ASCVD发病及严重程度的独立危险因素,同时作为共病也可能是ASCVD不良预后的独立预测因素。此外,肌少症与老年ASCVD之间存在共同的发病机制,如炎症、氧化应激及胰岛素抵抗等。该文就肌少症在老年ASCVD发病中的作用进行综述。
Atherosclerotic cardiovascular disease(ASCVD)is a kind of disease including acute coronary syndrome(ACS),history of myocardial infarction(MI),stable or unstable angina pectoris(SAP,UAP),coronary artery or other blood vessel revascularization(PCI),ischemic stroke(IS),transient ischemic attack(TIA),peripheral vascular disease(PAD)and so on.It has a high morbidity rate,high disability rate,and high mortality rate in elderly patients,which puts a heavy burden on patients'families and society.But the early warning markers of ASCVD were still in the exploratory stage.Sarcopenia is a common disease in elderly individuals.A large number of studies showed that sarcopenia may be an independent risk factor for the onset and severity of ASCVD.As a comorbidity,at the same time,it may also be an independent predictor of poor prognosis of ASACVD.In addition,sarcopenia and ASCVD in elderly individuals have some common pathogenesis,such as inflammation,oxidative stress and insulin resistance.The role of sarcopenia in the pathogenesis of ASCVD in the elderly is reviewed in present paper.
作者
陈长
刘辉
蔺阳刚
刘芝兰
辛佳艳
王庆松
Chen Zhang;Liu Hui;Lin Yang-Gang;Liu Zhi-Lan;Xin Jia-Yan;Wang Qing-Song(Medical College,Southwest Jiaotong University,Chengdu 610031,China;Department of Neurology,General Hospital of Western Theater Command of PLA,Chengdu 610500,China;Clinical Department of Medical Science,North Sichuan Medical College,Nanchong,Sichuan 637000,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2021年第5期512-517,共6页
Medical Journal of Chinese People's Liberation Army
基金
四川省卫生和计划生育委员会科研课题(16PJ014)。
