摘要
目的总结Kupffer细胞(KCs)与肝脏疾病的关系。方法收集整理近年来关于KCs与肝脏疾病关系的相关文献并进行综述。结果KCs是机体单核巨噬细胞系统的重要组成成分,在特定的环境下,活化的KCs通过呈递抗原、分泌细胞因子及趋化因子、吞噬作用等参与多种炎症反应、免疫耐受以及对肝细胞的侵害过程。KCs既可活化为M1型,促进炎症反应的发生,加剧肝细胞损伤;又可被激活为M2型,发挥抗炎作用,改善肝脏损伤。KCs在肝脏疾病中的作用十分复杂,但其也具有潜在的研究价值。结论KCs通过多种机制影响肝脏疾病的进展,能为肝脏疾病的预防与治疗提供新的思路。
Objective To summarize the relationship between Kupffer cells(KCs)and liver diseases.Methods The related literatures about the research progress of KCs in liver diseases in recent years were collected and analyzed.Results KCs were an important component of the monocyte-macrophage system.In a specific environment,activated KCs participated in a variety of inflammatory reactions,immune tolerance,and damage to hepatocytes by presenting antigens,secreting cytokines and chemokines,phagocytosis,and so on.KCs could not only be activated into M1 to promote inflammatory reaction and aggravate hepatocyte injury,but also could be activated to M2 to play an antiinflammatory effect and improve liver injury.The role of KCs in liver diseases was very complex,but it also had potential research value.Conclusion KCs can affect the progression of liver diseases through many mechanisms and can provide new ideas for the prevention and treatment of liver diseases.
作者
徐洋
麻勇
XU Yang;MA Yong(Department of Hepatic Surgery,The First Affiliated Hospital of Harbin Medical University/Key Laboratory of Hepatosplenic Surgery,Ministry of Education,Harbin 150001,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2021年第5期673-677,共5页
Chinese Journal of Bases and Clinics In General Surgery
基金
国家自然科学基金资助项目(项目编号:81100305、81470876)
黑龙江省自然科学科学基金(项目编号:LC2018037)
博士后研究人员落户黑龙江科研启动资助金(项目编号:LBH-Q17097)。
