摘要
目的评估高龄女性PCI的3年预后情况。方法连续入选2004年1月~2015年12月行PCI的年龄≥61岁女性患者1083例,患者年龄61~97岁,将年龄≥80岁的146例作为女性高龄组、年龄<80岁的937例作为女性老年组,同期选择年龄≥80岁的男性患者113例作为男性高龄组。收集患者基线临床资料,随访3年,记录主要不良心血管事件(MACE)等临床终点事件。用倾向性评分逆概率加权法(IPTW)校正混杂因素,用Kaplan-Meier生存曲线分析。结果IPTW校正后,各组基线临床特征比较,均无统计学差异(P>0.05)。随访3年期间,与男性高龄组比较,女性高龄组MACE发生率无显著差异(16.4%vs 10.6%,Plog rank>0.05),经IPTW校正后,2组发生主要临床终点事件的风险相似(Plog rank>0.05),与女性老年组比较,女性高龄组心源性死亡和MACE发生率明显升高(12.3%vs 3.0%,Plog rank=0.000,16.4%vs 10.6%,Plog rank=0.023),但经IPTW校正后,2组比较无显著差异(Plog rank>0.05)。结论高龄女性行PCI不增加MACE风险,安全可行。
Objective To assess the 3-year outcome of very old female CHD patients after PCI.Methods A total of 1083 elderly female CHD patients who underwent PCI in our hospital from January 2004 to December 2015 were divided into very old(≥80 years old)female group(n=146)and elderly(<80 years old)female group(n=113)with 113≥80 years old male patients served as a very old male group.The patients were followed up for 3 years,during which the MACE were recorded.The confounding factors were adjusted with the IPTW and analyzed by Kaplan-Meier survival curve analysis.Results No significant difference was detected in baseline clinical characteristics of different groups after adjustment with IPTW(P>0.05)and in incidence of MACE between very old male group and very old female group during the 3-year follow-up period(16.4%vs 10.6%,Plog rank>0.05).The risk of MACE was similar between the two groups after adjustment with IPTW(Plog rank>0.05).The incidence of cardiogenic death and MACE was significantly higher in very old female group than in elderly female group(12.3%vs 3.0%,Plog rank=0.000;16.4%vs 10.6%,Plog rank=0.023)with no significant difference detected between the two groups after adjustment with IPTW(Plog rank>0.05).Conclusion PCI does not increase the risk of MACE and is thus safe and feasible for very old female patients.
作者
王家瑞
王鹏
郭少华
陈康寅
Rha Seungwoon
李新
Wang Jiarui;Wang Peng;Guo Shaohua;Chen Kangyin;Rha Seungwoon;Li Xin(Tianjin Medical University No.2 Hospital,Tianjin 300211,China)
出处
《中华老年心脑血管病杂志》
北大核心
2021年第6期575-577,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
女性
经皮冠状动脉介入治疗
利尿药
预后
femininity
percutaneous coronary intervention
diuretics
prognosis
