摘要
目的:探讨混合磨玻璃结节肺腺癌的CT表现与其病理等级的相关性。方法:选取我院胸部CT表现为混合磨玻璃肺结节,并经手术病理证实为肺腺癌的118例患者的资料,根据病理性质分为三组,其中原位腺癌组、微浸润性腺癌组、浸润性腺癌组分别为17、29、72例。比较三组患者混合磨玻璃肺结节整体及实性成分CT表现。对结节的大小、实性成分的大小、实性成分的比例、实性成分的CT值绘制受试者工作特征曲线(receiver operating characteristic curve, ROC),确定预测浸润性腺癌的最佳截值,并计算敏感度、特异度。结果:混合磨玻璃肺结节的大小、形状、空气支气管征、血管集束征、胸膜凹陷征在三组间比较,差异有统计学意义(P<0.05)。实性成分的大小、实性成分的比例、实性成分的CT值、实性成分的边界在三组间比较,差异有统计学意义(P<0.05)。结节的大小预测浸润性腺癌的最佳截值为15.5 mm,其敏感度为0.792,特异度为0.783。实性成分的大小预测浸润性腺癌的最佳截值为5.5 mm,其敏感度为0.764,特异度为0.811。实性成分的比例预测浸润性腺癌的最佳截值为38.7%,其敏感度为0.736,特异度为0.935。实性成分的CT值预测浸润性腺癌的最佳截值为-149.0 HU,其敏感度为0.694,特异度为0.826。结论:混合磨玻璃结节肺腺癌的CT表现与其病理等级有一定的相关性,结节的大小、实性成分的大小、实性成分的比例、实性成分的CT值对其病理等级有重要的预测价值。
Objective:To investigate correlation between CT findings and pathological grade of mixed ground-glass nodule of lung adenocarcinoma.Methods:The data of 118 patients with mixed ground-glass lung nodules on chest CT and lung adenocarcinoma confirmed by surgery and pathology were selected.According to the pathological characteristics,they were divided into three groups,including 17,29 and 72 cases of adenocarcinoma in situ group,minimally invasive adenocarcinoma group and invasive adenocarcinoma group respectively.The overall CT findings and solid components CT findings of mixed ground-glass lung nodules in the three groups were compared respectively.Receiver operating characteristic curve(ROC)was drawn on the size of nodules,the size of solid components,the proportion of solid components,and the CT value of solid components to determine the best cut-off value for predicting invasive adenocarcinoma,and calculate the sensitivity and specificity.Results:The size,shape,air bronchogram sign,vascular convergence sign and pleural indentation sign of mixed ground-glass pulmonary nodules were compared among the three groups,and the differences were statistically significant(P<0.05).The size of the solid component,the proportion of the solid component,the CT value of the solid component and the boundary of the solid component were compared among the three groups,and the differences were statistically significant(P<0.05).The best cut-off value for predicting invasive adenocarcinoma by the size of nodule was 15.5 mm,with sensitivity of 0.792 and specificity of 0.783.The best cut-off value for predicting invasive adenocarcinoma by the size of solid component was 5.5 mm,with sensitivity of 0.764 and specificity of 0.811.The best cut-off value for predicting invasive adenocarcinoma by the proportion of solid component was 38.7%,with sensitivity of 0.736 and specificity of 0.935.The best cut-off value for predicting invasive adenocarcinoma by the CT value of solid component was-149.0 HU,with sensitivity of 0.694 and specificity of
作者
李丽
郭孟刚
何正光
罗晓斌
赵勇
杜发旺
王述红
曾浩
LI Li;GUO Menggang;HE Zhengguang;LUO Xiaobin;ZHAO Yong;DU Fawang;WANG Shuhong;ZENG Hao(Department of Respiratory and Critical Medicine,Suining Central Hospital,Sichuan Suining 629000,China;Department of Thoracic Surgery,Suining Central Hospital,Sichuan Suining 629000,China;Department of Radiology,Suining Central Hospital,Sichuan Suining 629000,China)
出处
《现代肿瘤医学》
CAS
北大核心
2021年第11期1888-1893,共6页
Journal of Modern Oncology
基金
四川省卫生健康委科技项目(编号:17PJ037)。
关键词
混合磨玻璃结节
肺腺癌
实性成分
计算机体层成像
mixed ground-glass nodule
lung adenocarcinoma
solid component
computed tomography
