摘要
干眼病(dry eye disease,DED)是一种多因素的眼表疾病,其发病机制复杂,发病率逐年升高,临床上只能针对症状进行缓解,严重影响患者生活质量。本文介绍了DED的多种病因、发病机制和目前常见的动物模型,并重点介绍了动物模型与临床DED发病机制的相关性,以期为DED动物模型的发展和改进提供思路。
Dry eye disease (DED) is a multi-factor ocular surface disease with complex pathogenesis and an increasing incidence rate.Clinical treatment can only relieve symptoms,which seriously affects the quality of patients’ life.This paper introduces etiologies,pathogenesis and animal models of DED,and focuses on the correlation between animal models and clinical pathogenesis of DED,in order to provide ideas for the development and improvement of DED animal models.
作者
宋硕
王若男
谢金华
孟永
熊亚妮
钱仪敏
李华
SONG Shuo;WANG Ruonan;XIE Jinhua;MENG Yong;XIONG Yani;QIAN Yitnin;LI Hua(National Shanghai Center for New Drug Safety Evaluation and Research of China State Institute of Pharmaceutical Industry,Shunghai 201203,China;Shanghai InnoStar Bio-tech Co.,Ltd.,Shanghai 201203,China;IimoStar Bio-tech Nantong Co.,Ltd.,Nantong 226133,Jiangsu Province,China)
出处
《世界临床药物》
CAS
2021年第4期296-302,320,共8页
World Clinical Drug
基金
十三五国家“重大新药创制”科技重大专项(2018ZX09201017-008)
上海市科委研发平台专项上海市科委(18DZ2290100)。
关键词
干眼病
病因
发病机制
动物模型
dry eye
cause of disease
pathogenesis
animal models
