摘要
目的探究"小续命汤"对急性大动脉粥样硬化性缺血性脑卒中风痰瘀阻型患者的有效性和安全性。方法共纳入98例发病7天内的符合入组标准的急性缺血性脑卒中患者,随机、双盲分为2组,试验组为小续命汤组,对照组为安慰剂组,治疗前后分别采用美国国立卫生院卒中量表(the national institutes of health stroke scale,NIHSS)、Bathel指数(barthel index,BI)、改良的Rankin量表(modified rankin scale,mRS)和中医临床疗效进行评价,并对安全性指标进行检测。结果治疗后3个月,小续命汤组NIHSS评分下降优于安慰剂组(P<0.01),BI评分较安慰剂组明显提高(P<0.001),mRS评分下降优于安慰剂组(P<0.01)。结果显示,小续命汤组治疗后3个月中医临床疗效优于安慰剂组(P<0.01)。两组谷丙转氨酶(alanine aminotransferase,ALT)升高发生率差异无统计学意义(P>0.05)。结论小续命汤治疗早期急性风痰瘀阻型大动脉粥样硬化性缺血性脑卒中是有效和安全的,可以改善患者的神经功能缺损、降低残障程度,提高日常生活能力和中医临床疗效。
Objective To explore the efficacy and safety of "Xiaoxuming Decoction" in wind phlegm stasis patients with acute atherosclerotic ischemic stroke.Method A total of 98 patients with acute ischemic stroke who met the inclusion criteria within 7 days of onset were included,which were randomly,double-blindly divided into experimental group (Xiaoxuming decoction group) and control group (placebo group).The national institutes of health stroke scale (NIHSS),Bathel index (BI),modified Rankin scale (mRS) and clinical efficacy of traditional Chinese medicine were evaluated before and after treatment,and the safety indicators were tested.Results After 3 months of treatment,the score of NIHSS and mRS were significantly lower than placebo group (P<0.01),while the score of BI was obviously higher than that of placebo group(P<0.001).The clinical efficacy of Xiaoxuming decoction group had better outcomes than placebo group (P<0.01).There was no significant difference in the incidence of alanine aminotransferase (ALT) elevation between two groups(P>0.05).Conclusion Xiaoxuming decoction was effective and safe in the early treatment of acute atherosclerotic ischemic stroke with wind phlegm stasis.It can improve the neurological deficits,reduce the level of disability,improving daily living ability and clinical efficacy of traditional Chinese medicine in patients.
作者
周叶
胡春梅
王洁
朱瑾
ZHOU Ye;HU Chunmei;WANG Jie;ZHU Jin(Department of Neurology,Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai 201900,China;Department of Neurology,Baoshan Branch,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201900,China)
出处
《世界临床药物》
CAS
2021年第4期279-284,共6页
World Clinical Drug
基金
上海市卫生和计划生育委员会科研课题(201640195)。
关键词
小续命汤
急性缺血性脑卒中
风痰瘀阻证
Xiaoxuming decoction
acute ischemic stroke
syndrome of Fengtanyuzu
