摘要
目的研究利奈唑胺、万古霉素联合美罗培南对小儿细菌性脑膜炎脑脊液细胞学及远期疗效的影响。方法选择2015年1月至2020年3月在我院住院治疗的细菌性脑膜炎患儿68例为研究对象,随机分为研究组(n=34)和对照组(n=34)。其中研究组均实施利奈唑胺联合美罗培南治疗;对照组均实施万古霉素联合美罗培南治疗。分别记录并比较两组患儿的临床疗效及脑脊液(CSF)细胞学、降钙素原(PCT)和腺苷脱氨酶(ADA)、C反应蛋白(CRP)水平,氯化物、葡萄糖、蛋白质、白细胞数和脑脊液压力水平,随访两个月,比较其不良反应及后遗症等远期疗效。结果研究组患儿的治疗总有效率为97.06%高于对照组的76.47%,差异有统计学意义(P<0.05)。治疗前,两组患儿的氯化物、葡萄糖等CSF细胞学指标比较,差异无统计学意义(P>0.05)。治疗后,两组患儿的CSF细胞学指标均明显改善,且研究组优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿的PCT、ADA比较,差异无统计学意义(P>0.05)。治疗后,两组患儿PCT、ADA水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿的CRP比较,差异无统计学意义(P>0.05)。治疗后,两组患儿CRP水平低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。两组患儿的不良反应及后遗症对比,差异无统计学意义(P>0.05)。结论利奈唑胺联合美罗培南在治疗小儿细菌性脑膜炎中具有较好的临床疗效,可显著改善其CSF细胞学指标、炎症因子以及PCT、ADA水平,值得临床推广使用。
Objective To investigate the impacts of linezolid,vancomycin combined with meropenem on cerebrospinal fluid cytology and long-term efficacy in children with bacterial meningitis.Methods A total of 68 children with bacterial meningitis admitted to our hospital from January 2015 to March 2020 were selected as research objects,and they were randomly divided into the study group(n=34)and the control group(n=34).Among them,the study group was treated with linezolid combined with meropenem,while the control group was treated with vancomycin combined with meropenem.The clinical efficacy,cerebrospinal fluid(CSF)cytology,procalcitonin(PCT),adenosine deaminase(ADA)and C-reactive protein(CRP)levels,chloride,glucose,protein,white blood cell count and cerebrospinal fluid pressure levels of the two groups of children were recorded and compared respectively.They were followed up for two months,and the long-term efficacy such as adverse reactions(ADRs)and sequelae were compared.Results The overall response rate of children in the study group was 97.06%,higher than 76.47%in the control group,with statistically significant difference(P<0.05).Before treatment,there were no statistically significant differences in CSF cytological indexes such as chloride and glucose between the two groups(P>0.05).After treatment,the CSF cytological indexes of the two groups of children were all significantly improved,and the study group was superior to the control group,with statistically significant differences(P<0.05).Before treatment,there were no statistically significant differences in PCT and ADA between the two groups of children(P>0.05).After treatment,the PCT and ADA levels decreased significantly in both groups,and study group was lower than that in the control group,with statistically significant differences(P<0.05).Before treatment,there was no statistically significant difference in CRP between the two groups of children(P>0.05).After treatment,the CRP levels decreased significantly in both groups,and study group was lower than that in
作者
梁森全
莫庆仪
黄晓雯
葛晓宁
LIANG Senquan;MO Qingyi;HUANG Xiaowen;GE Xiaoning(Department of Pediatrics,Boai Hospital of Zhongshan,Guangdong,Zhongshan 528400,China)
出处
《中国医药科学》
2021年第9期67-70,86,共5页
China Medicine And Pharmacy
