摘要
固体制剂作为最常用的给药形式,对制剂原料及产品均有较高的要求。多孔粉体具有相对密度低、孔隙率和比表面积大、渗透性和吸附性好等特点,对制剂过程及终产品具有显著影响。多孔粉体的制备工艺及多孔结构类型对其性质有一定的影响,从而影响其在药物固体制剂中的应用。因此,基于近年来国内外的相关研究,笔者综述了固体制剂中多孔粉体的制备方法、分类及其应用,为后续多孔粉体的研究及其在药物制剂中的进一步广泛应用奠定了良好的研究基础。
As the most commonly used form of administration,solid preparations have higher requirements for preparation materials and products.The porous powder exhibits the characteristics of low relative density,large porosity and specific surface area,good permeability and adsorption,etc.,which have significant impact on the preparation process and the final product.The preparation process and porous structure type of porous powder have a certain influence on their properties,thereby affecting their application in solid pharmaceutical preparations.Therefore,based on the relevant research at home and abroad in recent years,this paper summarized the preparation methods,classification and application of porous raw materials in pharmaceutical solid preparations,which lais a good research foundation for the subsequent research of porous powder and their further wide application in pharmaceutical preparations.
作者
朱卫丰
朱琳
明良山
管咏梅
陈丽华
李哲
ZHU Wei-feng;ZHU Lin;MING Liang-shan;GUAN Yong-mei;CHEN Li-hua;LI Zhe(Key Laboratory of Modern Preparation of TCM,Ministry of Education,Institute for Advanced Stuedy,Research Center for Differentiation and Development of TCM Basic Theorv.lani lnersiy of Chinese Medicine.Nanchunr 330004.China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2021年第8期613-619,共7页
Chinese Pharmaceutical Journal
基金
国家重点研发计划“中医药现代化”专项项目资助(2017YFC1702900)
国家自然科学基金项目资助(82003953)
中国博士后科学基金资助项目(2019M662278)
江西省自然科学基金项目资助(20202BAB216039)
江西省教育厅科学技术研究项目资助(GJJ190688)
江西省博士后科研项目择优资助(2019KY42)
江西省博士后日常资助(2020RC15)
江西中医药大学校级课题资助(2004/538200010402)。
关键词
固体制剂
多孔粉体
制备
分类
应用
solid preparation
porous powder
preparation
classification
application
