摘要
目的观察阿仑膦酸钠片联合依降钙素对骨质疏松(OP)骨折患者术后骨痛的影响。方法将126例OP骨折的患者依据随机数字法分为对照组63例与试验组63例。对照组在常规使用骨质疏松症药物基础上给予阿仑磷酸钠片,每次70 mg,每周1次,口服。试验组在对照组的基础上给予依降钙素:治疗前7 d,每次50 U,每天1次,肌内注射;治疗第8天开始,每次50 U,隔日1次,肌内注射;治疗第14天开始,每次50 U,隔3天1次,肌内注射。连续注射28 d为1个疗程。2组均治疗6个月。比较2组患者1,25-二羟维生素D3(1,25-(OH)2D3)、甲状旁腺激素(PTH)、腰椎(L1~4)骨密度、股骨颈骨密度、髋部骨密度、视觉模拟评分(VAS),以及药物不良反应发生情况。结果治疗后,试验组和对照组的1,25-(OH)2D3分别为(25.97±2.86)和(20.35±2.85)mmol·L^(-1),PTH分别为(60.58±6.66)和(73.58±10.30)ng·L^(-1),腰椎(L1~4)骨密度分别为(0.84±0.10)和(0.72±0.11)g·cm^(-3),股骨颈骨密度分别为(0.85±0.13)和(0.74±0.10)g·cm^(-3),髋部骨密度分别为(0.85±0.13)和(0.79±0.10)g·cm^(-3),差异均有统计学意义(均P<0.05)。治疗后,试验组和对照组在静止、翻身、弯腰、步行、叩击、按压状态下的VAS比较,差异均有统计学意义(均P<0.05)。试验组和对照组在治疗过程中的药物不良反应发生率分别为17.46%和14.29%,差异无统计学意义(P>0.05)。结论采用阿仑膦酸钠片联合依降钙素的方案治疗骨质疏松骨折的患者,可以提升患者的骨密度值,降低骨痛程度,提升疗效,具有良好的安全性。
Objective To observe the effect of alendronate sodium tablets combined with elcatonin on postoperative bone pain in patients with osteoporotic(OP) fractures. Methods According to the random number method, 126 patients with OP fractures were divided into control group of 63 cases and treatment group of 63 cases. Control group was given alendronate sodium tablets on the basis of routine use of osteoporosis drugs, 70 mg each time, qw, orally;treatment group was given elcatonin on the basis of control group: 1-7 d treatment, 50 U each time, qd, intramuscular injection, on the 8 th day of treatment, 50 U, qod, intramuscular injection each time, on the 14 th day of treatment, 50 U each time, q3d, intramuscular injction. 28 d a course, the treatment time for both groups was 6 months. The 1,25-dihydroxyvitamin D3( 1,25-( OH) 2 D3),parathyroid hormone( PTH),lumbar spine( L1-4) bone mineral density,femoral neck bone mineral density,hip bone mineral density,visual analogue score( VAS),and adverse drug reactions in two groups were compared. Results After treatment,the 1,25-( OH) 2 D3 in treatment group and control group were( 25. 97 ± 2. 86) and( 20. 35 ± 2. 85) mmol·L^(-1),PTH were( 60. 58 ± 6. 66) and( 73. 58 ± 10. 30) ng·L^(-1),lumbar spine( L1-4) bone density were( 0. 84 ± 0. 10) and( 0. 72 ± 0. 11) g·cm^(-3),femoral neck bone density were( 0. 85 ± 0. 13) and( 0. 74 ± 0. 10) g · cm^(-3),hip bone density were( 0. 85 ± 0. 13) and( 0. 79 ± 0. 10)g·cm^(-3),all with statistically significant differences( all P < 0. 05). After treatment,there were statistically significant differences in VAS between treatment group and control group in static,turning over,bending,walking,percussion and pressing( all P < 0. 05). The incidence of adverse drug reactions in treatment group and control group during treatment were 17. 46% and 14. 29%,the difference without statistically significant( P > 0. 05). Conclusion Using alendronate sodium tablets combined with elcatonin to treat patients with osteoporotic fractures can increas
作者
陈学青
张英剑
商福青
CHEN Xue-qing;ZHANG Ying-jian;SHANG Fu-qing(Department of Orthopedics,Baodi Clinical College,Tianjin Medical University,Tianjin 301800,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2021年第9期1059-1062,共4页
The Chinese Journal of Clinical Pharmacology
