摘要
目的观察氟比洛芬酯(FA)联合右美托咪定(DEX)对强化麻醉下甲状腺术患者术后苏醒及疼痛的效果。方法将择期强化麻醉下进行单侧甲状腺部分切除术68例患者随机分为对照组和试验组,每组34例。入室后开放静脉通路,对照组给予DEX负荷量1μg·kg^(-1)·min^(-1)泵入10 min,后改为0.5μg·kg^(-1)·min^(-1)泵注维持;试验组给予FA 50 mg静脉滴注,DEX负荷量1μg·kg^(-1)·min^(-1)泵入10 min,后改为0.5μg·kg^(-1)·min^(-1)泵注维持。记录入室开放静脉通路基础值(T_(0))、注射药物时(T_(1))、手术开始15 min(T_(2))、手术开始30 min(T_(3))、术毕(T_(4))心率(HR)、无创平均动脉压(MAP)、脉搏氧饱和度(SpO_(2))、呼吸频率(RR),评估术后1 (T_(5)),2(T_(6)),4(T_(7)),8(T_(8)),12(T_(9))和24 h(T_(10))镇静、疼痛程度,统计术后药物不良反应发生情况。结果试验组和对照组T_(1)时间的MAP分别为(72.83±7.87)和(88.63±9.55)mmHg, T_(2)时间分别为(73.93±7.72)和(90.17±9.68)mmHg, T_(3)时间分别为(71.82±7.29)和(86.28±9.06)mmHg, T_(4)时间分别为(70.48±7.16)和(79.73±8.60)mmHg, T_(1)时间HR分别为(64.27±7.27)和(83.37±8.82)beats·min^(-1),T_(2)时间分别为(60.88±7.06)和(80.11±8.35)beats·min^(-1),T_(3)时间分别为(59.63±6.88)和(73.15±7.66)beats·min^(-1),T_(4)时间分别为(62.36±6.93)和(71.88±7.33)beats·min^(-1),镇静Ramsay评分T_(5)时间分别为(2.85±0.35)和(2.13±0.26)分,T_(6)时间分别为(2.80±0.34)和(2.09±0.25)分,T_(7)时间分别为(2.52±0.32)和(1.91±0.21)分,T_(8)时间分别为(1.74±0.22)和(1.59±0.20)分,疼痛VAS评分T_(5)时间分别为(2.47±0.34)和(2.85±0.40)分,T_(6)时间分别为(2.32±0.31)和(2.76±0.37)分,T_(7)时间分别为(2.07±0.28)和(2.41±0.32)分,T_(8)时间分别为(1.82±0.24)和(2.01±0.27)分,T_(9)时间分别为(1.43±0.20)和(1.65±0.22)分,T_(10)时间分别为(1.16±0.13)和(1.36±0.17)分,差异均有统计学意义(均P<0.05)。试验组和对照组的药物不良反应主要有头
Objective To investigate the effect flurbiprofen ester(FA) combined with dexmedetomidine(DEX) in patients after the thyroidectomy with intensified anesthesia in revival and pain. Methods A total of 68 patients undergoing unilateral partial thyroidectomy under local anesthesia and intensive anesthesia were randomly divided into control group and treatment group,34 cases in each group. After entering the room,the venous access was opened,control group was given DEX at loading dose of 1μg·kg^(-1)·min^(-1) pump for 10 min,then changed to 0. 5 μg·kg^(-1)·min^(-1) maintenance,treatment group was given FA 50 mg intravenous drip,DEX at loading dose of 1 μg · kg^(-1)·min^(-1) pump for 10 min,then changed to 0. 5μg·kg^(-1)·min^(-1) maintenance. Heart rate( HR), noninvasive mean arterial pressure( MAP), pulse oxygen saturation( SpO_(2)),respiratory rate( RR) were compared at before open vein access based value( T_(0)),injection of local anesthetic drugs( T_(1)),the operation began operation of 15 min( T_(2)),30 min( T_(3)) and the end of operation( T_(4)),and levels of pain,postoperative adverse reaction statistics were recorded at postoperative 1( T_(5)),2( T_(6)),4( T_(7)),8( T_(8)),12( T_(9)),24 h after operation( T_(10)). Results MAP in treatment group and control group at T_(1) were( 72. 83 ± 7. 87) and( 88. 63 ± 9. 55) mmH g,T_(2) were( 73. 93 ± 7. 72) and( 90. 17 ± 9. 68) mmH g,T_(3) were( 71. 82 ± 7. 29) and( 86. 28 ± 9. 06) mmH g,T_(4) were( 70. 48 ± 7. 16) and( 79. 73 ± 8. 60) mmH g,HR at T_(1) were( 64. 27 ± 7. 27) and( 83. 37 ± 8. 82) beats·min^(-1),T_(2) were( 60. 88 ± 7. 06) and( 80. 11 ± 8. 35) beats·min^(-1),T_(3) were( 59. 63 ± 6. 88) and( 73. 15 ± 7. 66) beats·min^(-1),T_(4) were( 62. 36 ± 6. 93) and( 71. 88 ± 7. 33) beats·min^(-1),Ramsay score of sedation at T_(5) were( 2. 85 ± 0. 35) and( 2. 13 ± 0. 26) scores,T_(6) were( 2. 80 ± 0. 34) and( 2. 09 ± 0. 25) scores,T_(7) were( 2. 52 ± 0. 32) and( 1. 91 ± 0. 21) scores,T_(8) were( 1. 74 ± 0. 22) and( 1. 59 ± 0. 20) sc
作者
刘艳萍
胡建军
白杨
闫睿
LIU Yan-ping;HU Jian-jun;BAI Yang;YAN Rui(Department of Anesthesia,the 3rd Affiliated Clinical Hospital of Xinjiang Medical University,Affiliated Cancer Hospital,Urumqi 830011,Xinjiang Uygur Autonomous Region,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2021年第9期1052-1055,共4页
The Chinese Journal of Clinical Pharmacology
基金
新疆维吾尔自治区自然科学基金资助项目(2018D01C259)。
