摘要
抗磷脂综合征(APS)是以血栓形成为病理基础的自身免疫性疾病,同时有抗磷脂抗体谱(aPLs)的持续阳性。aPLs是诊断APS的关键。目前临床应用的抗磷脂抗体主要包括抗心磷脂抗体(aCL)、抗β2糖蛋白Ⅰ抗体(aβ2GPI)和狼疮抗凝物(LA)。但在临床实践中发现目前仅基于这3种aPLs的APS的实验室诊断标准存在较多缺陷,不能满足临床需求。本文通过总结近年来抗磷脂抗体谱的研究与发展,对IgA型抗体谱、抗β2GPI结构域I抗体等非分类标准抗体在临床应用中的价值进行综述。
Antiphospholipid syndrome(APS)is a autoimmune system disorder caused by thrombosis and is usually accompanied with persistent positive.Antiphospholipid antibodies profiles(aPLs)is the key to diagnosing APS.The most frequently detectable aPLs in current clinical applications are anticardiolipin antibodies(aCL),anti-β2 glycoproteinⅠantibodies(anti-β2 GPI),and lupus anticoagulant(LA).However,it is found that the current laboratory diagnostic standard for APS based on these three aPL have many defects.The standard can′t meet the clinical needs.In this article,the research and development of antiphospholipid antibody in recent years are summarized,and the clinical value of non-classified standard antibodies such as IgA antibody isotype and anti-domain 1 β2-glycoprotein I antibody are reviewed.
作者
翟晓丹
杨硕
崔丽艳
Zhai Xiaodan;Yang Shuo;Cui Liyan(Department of Laboratory Medicine,Peking University Third Hospital,Beijing 100191,China)
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2021年第4期347-351,共5页
Chinese Journal of Laboratory Medicine
基金
国家自然科学基金(62071011)。
关键词
抗磷脂综合征
抗磷脂抗体谱
诊断标准
Antiphospholipid syndrome
Antiphospholipid antibody
Diagnostic criteria
