摘要
目的采用序贯法分阶段分别测定丙泊酚复合瑞芬太尼用于小儿无肌松气管插管中的半数有效剂量(median effective dose,ED_(50))及95%有效剂量(95%effective dose,ED95)。方法选择择期手术患儿70例,年龄1~3岁,ASAⅠ或Ⅱ级,分阶段进行序贯试验。第一阶段固定丙泊酚诱导剂量3.5 mg/kg,测瑞芬太尼ED_(50)、ED95;第二阶段固定瑞芬太尼ED95,测丙泊酚ED_(50)、ED95。用probit概率单位法计算ED及95%CI。结果瑞芬太尼ED_(50)2.50(1.91,3.28)μg/kg、ED953.91(3.19,9.53)μg/kg;丙泊酚ED_(50)2.34(1.73,2.94)mg/kg、ED953.67(3.02,8.65)mg/kg。结论丙泊酚复合瑞芬太尼可安全用于1~3岁小儿无肌松气管插管,丙泊酚ED_(50)、ED95,瑞芬太尼ED_(50)、ED95可为临床提供精准用药依据。
Objective The purpose of this study was to determine the median and 95 percent effective doses(ED_(50),ED95)of propofol and remifentanil for endotracheal intubation without muscle relaxant in pediatric patients using a sequential method.Methods In two stages,70 children undergoing elective surgery were chosen for the sequential trial.In the first stage,the induction dose of propofol was fixed at 3.5 mg/kg,and the ED_(50) and ED95 of remifentanil were measured.In the second stage,the ED95 of remifentanil was fixed,and the ED_(50) and ED95 of pro⁃pofol were measured.Using the probit probability unit process,the ED and 95 percent confidence interval(CI)were measured.Results The ED_(50) of remifentanil was 2.50(95%CI 1.91,3.28)μg/kg,and the ED95 was 3.91(3.19,9.53)μg/kg.The ED_(50) of propofol was 2.34(1.73,2.94)mg/kg,and the ED95 was 3.67(3.02,8.65)mg/kg.Conclusions Propofol and remifentanil can be used safely in children aged 1 to 3 years old for endotracheal intu⁃bation without the use of a muscle relaxant.Propofol and remifentanil have ED_(50) and ED95 values that can be used as a guide for specific drug administration。
作者
谭美云
赵秉诚
刘克玄
TAN Meiyun;ZHAO Bingcheng;LIU Kexuan(Depart-ment of Anesthesiology,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China)
出处
《实用医学杂志》
CAS
北大核心
2021年第10期1284-1287,共4页
The Journal of Practical Medicine
基金
中国博士后科学基金(编号:2019M662976)。
关键词
丙泊酚
瑞芬太尼
有效剂量
无肌松气管插管
propofol
remifentanil
effective dose
endotracheal intubation without muscle relaxants in children
