摘要
金黄色葡萄球菌(金葡菌)是常见人类致病菌之一。既往报道以杀白细胞素(Panton-Valentine Leukocidin,PVL)为代表的毒力蛋白为细菌侵袭人体后的重要致病因子。随研究不断深入,目前有学者认为pvl基因的存在对金葡菌致病力影响较小。本文旨在回顾并总结近年关于pvl特点、分子流行病学、致病性及争议之处的相关研究。
Staphylococcus aureus(S.aureus)is one of the most common human pathogens.It has been reported that Panton-Valentine Leukocidin(PVL)as a representative of virulence proteins is an important pathogenic factor for S.aureus infection.However,with the deepening of research,some researchers consider that pvl gene has little effect on the pathogenicity of S.aureus.This article aimed to review and summarize the recent studies on the features,molecular epidemiological characteristics,pathogenicity and controversy of pvl gene.
作者
李儒博
钱素云
Li Rubo;Qian Suyun(Pediatric Intensive Care Unit,National Center for Children′s Health,Beijing Children′s Hospital,Capital Medical University,Beijing 100045,China)
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2021年第4期313-317,共5页
Chinese Journal of Microbiology and Immunology
基金
北京市自然科学基金(7172075)。
关键词
金黄色葡萄球菌
杀白细胞素
争议
进展
Staphylococcus aureus
Panton-Valentine leucocidin
Controversy
Progress
