摘要
OBJECTIVE:To investigate the changes of subcortical gray matter volume and cortical thickness,andexplorethe correlations between regional abnormalities of cortical thickness and cognitive impairment and the effect of modified Bushenyisui decoction(补肾益髓汤,BSYSD)on the cognitive function of multiple sclerosis(MS).METHODS:This prospective study was approved by the institutional review board.92 subjects were recruited,including 46 relapsing-remitting multiple sclerosis(RRMS)patients and 46 healthy controls(HC).Of the 46 patients,22 patients experienced the treatment of BSYSD for half a year.A conventional three-dimensional T1-weighted sequence were acquired for all participants on a 3.0 tesla magnetic resonance system.Basic information,detailed cognitive scales Montreal Cognitive Assessment(MoCA),symbol digit modalities test(SDMT),immediate memory,delayed recall,and long-term recognition were evaluated.Subcortical gray matter volume and cortical thickness weremeasured by FreeSurfer.The correlations between cortical thickness which MS patients showed reduced with respect to HC and cognitive scales wereanalyzed by Pearson correlation in RRMS patients.The influence of modified BSYSD on MS patients'cognition was analyzed by paired T Test.RESULTS:MoCA,immediate memory,delayed recall,and long-term delayed recognition in RRMS were significantly decreased than those of HC.Gray matter atrophy measured by FreeSurfer showed mainly in thalamus and hippocampus of RRMS patients.Compared with HC,the cortical thickness of several regions in frontal lobe,parietal lobe,temporal lobe,hippocampal,cingulate gyrus,and fusiform gyrus of RRMS patients were decreased with significant difference.The regions of cortical thickness thinning related to MoCA,immediate memory,delayed recall,and long-term delayed recognition were temporal lobe and fusiform gyrus.Modified BSYSD could improve MoCA,SDMT,immediate memory,delayed recall,and long-term delayed recognition of MS patients,and it could promote the recovery of cognitive function in MS
基金
Supported by the Fund for BeijingScience&Technology Development of TCM:the Study on the Curative Effect and Mechanism of Modification of Bushenyisui Capsules against Multiple Sclerosis with Depression Based on Magnetic Resonance Multimodal Analysis(No.JJ2018-49)
the Effect of Bushenyisui Capsules on Cognitive Impairment in Patients with Relapsing and Multiple Sclerosis(No.QN2014-17)
To Explore the Mechanism of Bushenyisui Capsule in Reconstituting NMOSD Immune Balance Based on the Regulation of p38 MAPK Pathway by TAK1(No.QN2018-30)
Capital Medical University Scientific Research Cultivation Fund:Rl Promotes the Recovery of Neurological Function in Rats with Cerebral Hemorrhage through the Pathway of Microglial Cells Polarizing Different Neurons to Mediate the Neuroinflammatory Reaction after Cerebral Hemorrhage(No.PYZ2018142)
to Explore the Mechanism of Bushenyisui Capsule Promoting Myelin Sheath Regeneration in EAE Mice by Regulating Proliferation,Differentiation and Migration of OPC by Treg Derived Nov(No.PYZ2018141)
National Natural Science Foundation of China:to Explore the Mechanism of Catalpol Mediated Proliferation,Migration and Axonal Remyelination of OPC by CCN3 through the Synergetic Regulation of Cdc42 Signaling Pathway by GEFs and mir-148b-3p(No.81973599)
the Study on the Mechanism of Regulating the Axon Myelination through NF and NRG1(No.81473640)。
