摘要
机械敏感性离子通道是细胞表面机械力学刺激转化为细胞内电信号或化学信号的机械感受器。近年来,在真核生物中Piezo蛋白作为机械敏感性阳离子通道逐渐成为研究热点,Piezo1和Piezo2蛋白在哺乳动物不同器官和组织中表达,而骨关节等组织与力学传导直接相关,机械力的传导及引起的细胞内效应对骨科疾病的治疗和预防起着非常重要的作用。就Piezo蛋白机械敏感性离子通道在骨组织、软骨组织、骨髓组织、椎间盘组织以及在骨科疾病中的研究进展进行综述。
Mechanosensitive ion channels are mechanoreceptors that convert mechanical stimulation on the cell surface into intracellular electrical signal or chemical signal.In recent years,Piezo protein as a mechanically activated cation channel in eukaryotes has gradually become a research hotspot.Piezo1 and Piezo2 proteins are expressed in different organs and tissues of mammals,and tissues such as bones and joints are directly related to mechanical conduction.The intracellular effects caused by the conduction of mechanical force play a very important role in the treatment and prevention of orthopedic diseases.In this paper,the researches on Piezo protein mechanically activated cation channels in bone tissue,cartilage tissue,bone marrow tissue,intervertebral disc tissue and orthopedic diseases were reviewed.
作者
张超
王平
刘爱峰
张君涛
李远栋
Zhang Chao;Wang Ping;Liu Aifeng;Zhang Juntao;Li Yuandong(Orthopedics Department,the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300380,China)
出处
《国际生物医学工程杂志》
CAS
2021年第1期50-54,共5页
International Journal of Biomedical Engineering
基金
天津市卫生健康委员会中医、中西医结合科研专项课题(2019066,2017118)
王平劳模创新工作室-天津市教委资助项目(津教工[2016]3号)。
