摘要
目的分析中药序贯疗法治疗多囊卵巢综合征伴不孕的效果。方法选取2016年12月-2018年12月收治的多囊卵巢综合征伴不孕的患者114例,采用随机数字法分为两组。对照组给予克罗米芬治疗,观察组给予中药序贯疗法治疗,分析两组患者治疗后的临床效果。结果观察组中医证候总有效率(92.98%,53/57)高于对照组(78.95%,45/57),差异具有统计学意义(P<0.05)。两组治疗前血清激素、氧化应激因子水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后雌二醇(E2)、性激素结合球蛋白(SHBG)、超氧化物歧化酶(SOD)水平高于对照组,睾酮(T)、黄体生成素/卵泡刺激素(LH/FSH)、肝细胞生长因子(HGF)、丙二醛(MDA)、8-异前列腺素F2a(8-iso-PGF2a)水平低于对照组(P<0.05)。观察组排卵率和妊娠率分别为91.23%(52/57)和50.88%(29/57),高于对照组的77.19%(44/57)和31.58%(18/57),差异具有统计学意义(P<0.05)。结论中药序贯疗法治疗多囊卵巢综合征伴不孕可减轻氧化应激损伤,改善血清激素水平,提高排卵率和妊娠率。
Objective To analyze the effect of sequential therapy of traditional Chinese medicine in the treatment of polycystic ovarian syndrome with sterility.Methods From December 2016 to December 2018,114 patients with sterility of polycystic ovarian syndrome were randomly divided into two groups.The control group was treated with clomiphene and the observation group was treated with sequential therapy of traditional Chinese medicine,and the clinical effect of the two groups was analyzed.Results The total effective rate of TCM syndromes in the observation group(92.98%,53/57)was significantly higher than that in the control group(78.95%,45/57)(P<0.05).There was no significant difference in the levels of serum hormones or oxidative stress factors between the two groups before treatment(P>0.05).After treatment,the levels of estrogen(E2),sex hormone binding globulin(SHBG)and superoxide dismutase(SOD)in the observation group were higher than those in the control group.The levels of testosterone(T),luteinizing hormone/follicular stimulating hormone(LH/FSH),HGF,malondialdehyde(MDA),8-isoprostaglandin F2(8-iso-PGF2 a)were lower than those of the control group(P<0.05).The ovulatory rate and pregnancy rate in the observation group were 91.23%(52/57)and 50.88%(29/57),respectively,which were significantly higher than those in the control group[77.19%(44/57)and 31.58%(18/57),P<0.05].Conclusion Sequential therapy of traditional Chinese medicine can reduce oxidative stress injury,improve serum hormone level and increase ovulatory rate and pregnancy rate.
作者
杨阳
雷秀兵
陈纯涛
YANG Yang;LEI Xiubing;CHEN Chuntao(School of Clinical Medicine,Panzhihua University,Panzhihua 617000,Sichuan,China;Medical College of Panzhihua University,Panzhihua 617000,Sichuan,China;Sichuan Second Hospital of traditional Chinese medicine,Chengdu 610031,Sichuan,China)
出处
《中华中医药学刊》
CAS
北大核心
2021年第3期73-76,共4页
Chinese Archives of Traditional Chinese Medicine
基金
中华医学会临床医学科研专项基金(15120080098)
四川省科技厅基本科研项目(2018-4-504)。
关键词
中药序贯疗法
多囊卵巢综合征
不孕
血清激素
氧化应激
traditional Chinese medicine sequential therapy
polycystic ovary syndrome
infertility
serum hormone
oxidative stress
