摘要
巨噬细胞具有高度异质性和可塑性。在不同类型疾病或者同一疾病的不同阶段,巨噬细胞能够进行表型转化,从而发挥不同的功能。因此,针对不同疾病对巨噬细胞表型进行干预的治疗策略正在成为攻克炎症性疾病、自身免疫疾病及肿瘤等疾病的新手段,其极化调控机制的研究显得越来越重要。干扰素调节因子(interferon regulatory factors,IRFs)在调控巨噬细胞成熟及表型分化等方面发挥着重要作用。本文将根据近年的研究进展,对IRFs的蛋白结构以及激活模式进行总结,在此基础上对IRFs家族各个分子通过调控巨噬细胞表型参与疾病进程的作用机制、信号调控网络以及靶向药物研发前景展开综述,为相关疾病治疗探索新的潜在靶标。
Macrophages are highly plastic and heterogeneous.In different types of inflammatory diseases,or at different stages of the same disease,macrophages can undergo phenotypic transformation to elicit different functions.Hence,exploring new regulatory mechanism of macrophage polarization and seeking for new key mediators will lay the foundation for the diagnosis and treatment of macrophage-related diseases,such as inflammatory diseases,autoimmune diseases,and cancer.Interferon regulatory factors(IRFs)have been reported to play an important role in the maturation and differentiation of macrophages.In this review,we will describe the structure and modulation pattern of IRFs,and then further summarize the molecular mechanism and signal regulation network of IRFs in pathological processes of related diseases through controlling macrophage polarization.Our review will explore the new therapeutic strategy and potential drug targets for related diseases.
作者
郝舒姝
姜晨晨
冯黎黎
HAO Shu-shu;JIANG Chen-chen;FENG Li-li(Key Laboratory of Cardiovascular and Cerebrovascular Medicine,School of Pharmacy,Nanjing Medical University,Nanjing 211166,China;School of Stomatology,Nanjing Medical University,Nanjing 211166,China)
出处
《药学学报》
CAS
CSCD
北大核心
2021年第4期939-948,共10页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(82003764)
江苏省高校自然科学研究项目(19KJB350001)。
关键词
干扰素调节因子
巨噬细胞极化
炎症性疾病
药物靶标
interferon regulatory factor
macrophage polarization
inflammatory disease
drug target
