摘要
目的探讨氨甲环酸(TXA)治疗老年轻中度颅脑损伤(TBI)的临床疗效。方法选取30例老年轻中度TBI患者作为研究对象,按照随机数字表法分成TXA组及对照组,每组15例。TXA组在初始10 min内静脉注射0.9%氯化钠注射液100 mL配比的1 g TXA,然后在8 h内静脉滴注0.9%氯化钠注射液500 mL配比的1 g TXA维持;对照组输注同等量0.9%氯化钠注射液。评估2组颅内血肿变化、手术例数、入住神经外科重症监护病房(NICU)时间、住院时间、格拉斯哥预后量表(GOS)评分;观察TXA组使用TXA不良反应情况。结果2组治疗前血肿量比较,差异无统计学意义(P>0.05);TXA组治疗后血肿量少于对照组(P<0.05)。TXA组入住NICU时间及住院时间短于对照组(P<0.05)。TXA组GOS评分优于对照组(P<0.05)。2组手术例数方面比较,差异无统计学意义(P>0.05)。TXA组未见明显不良反应发生。结论对于老年轻中度TBI患者,早期(3 h内)使用TXA不仅能够控制进展性颅内出血,缩短入住NICU时间及住院时间,还可以改善预后。
Objective To investigate the clinical effect of tranexamic acid(TXA)on mild and moderate traumatic brain injury(TBI)in elderly patients.Methods A total of 30 elderly patients with mild and moderate TBI were selected as the research objects and divided into the TXA group and the control group according to the random number table method,with 15 cases in each group.In the TXA group,1 g of TXA mixed with 100 mL of 0.9%sodium chloride injection was injected intravenously within the first 10 minutes,and then 1 g of TXA mixed with 500 mL of 0.9 sodium chloride injection was injected intravenously within 8 hours for maintenance.The control group received the same amount of 0.9%sodium chloride injection.The changes of intracranial hematoma,the number of surgical cases,the time of admission to neurosurgical intensive care unit(NICU),hospital stay,Glasgow outcome scale(GOS)scorebetween the two groups were evaluated.The adverse reactions of TXA in the TXA group were observed.Results There was no statistically significant difference in the volume of hematoma between the two groups before operation(P>0.05).The volume of hematoma after operation in the TXA group was less than that in the control group(P<0.05).The time of admission to NICU and hospital stay in the TXA group were shorter than those in the control group(P<0.05).The GOS score of the TXA group was better than that of the control group(P<0.05).There was no statistically significant difference in the number of surgical cases between the two groups(P>0.05).There was no obvious adverse reactions in the TXA group.Conclusion For the elderly patients with mild and moderate TBI,the early use(within 3 hours)of TXA can not only control the progressive intracranial hemorrhage,shorten the time of admission to NICU and hospital stay,but also improve the prognosis of patient.
作者
郐国虎
刘杰
蒋伟
KUAI Guo-hu;LIU Jie;JIANG Wei(Department of Neurosurgery,Tianyou Hospital Affiliated to Wuhan University of Science and Technology,Wuhan Hubei 430064,China;Department of Neurosurgery,Daye People’s Hospital,Huangshi Hubei 435100,China;Department of Neurosurgery,TongJi Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan Hubei 430030,China)
出处
《局解手术学杂志》
2021年第6期541-543,共3页
Journal of Regional Anatomy and Operative Surgery
基金
湖北省科学技术厅自然科学基金面上项目(2020CFB512)
武汉科技大学校级一般项目(2020X26)。
关键词
老年人
颅脑损伤
氨甲环酸
预后
old people
traumatic brain injury
tranexamic acid
prognosis
