摘要
目的研究SLE患者血清细胞外基质金属蛋白酶诱导因子(CD147)变化,探讨其与SLE发生动脉粥样硬化的相关性。方法80例SLE患者根据颈动脉内膜中层厚度(IMT),分为内膜增厚组(A组)24例和内膜正常组(B组)56例,同时分别收集其年龄、BMI、血压、血TC、HDL-C、LDL-C、TG水平、尿蛋白定量(24 h)、ESR、CRP、抗心磷脂抗体、血肌酐、病程、治疗情况。以35名健康体检者为健康对照组(C组)。ELISA法检测3组血清CD147水平。分析SLE患者血清CD47水平与动脉粥样硬化的关系。统计方法采用t检验、χ^(2)检验、方差分析、Spearman相关分析、Logistic回归分析。结果①A组血清CD147水平[(238±30)pg/ml]较B组[(198±30)pg/ml]和C组[(150±26)pg/ml,F=67.908,P<0.01]升高;且SLE患者血清CD147水平与SLEDAI评分、尿蛋白定量(24 h)呈正相关(r=0.389,P<0.05;r=0.323,P<0.05)。②A组BMI、高血压比例、血TC、传统危险因素数量、尿蛋白定量(24 h)、SLEDAI、血清CD147指标明显高于B组(P均<0.05)。③Logistic回归分析结果显示,血清CD147[OR(95%CI)=1.039(1.014,1.065),P<0.05]、尿蛋白定量(24 h)[OR(95%CI)=2.598(1.033,6.534),P<0.05]为影响SLE患者颈动脉IMT的独立危险因素。结论血清CD147为SLE患者颈动脉内中膜增厚的独立危险因素。
Objective To Studythe extracellular matrix metalloproteinase inducer(CD147)changes in patients with systemic lupus erythematosus(SLE),and to study thecorrelation of CD147 level and athero-sclerosis in SLE.Methods Eighty patients with SLE in total were divided into intimal thickening group,(24 cases,group A)and normal intimal group(56 cases,group B)according to carotid intimamedia thickness(IMT)checked by carotid ultrasonography.In addition,their age,bodymass index,blood pressure,seral total cholesterol(TC),high density liptein cholestero(HDL-C),low density lipoprotein cholestero(LDL-C),triglyceride(TG),urinary protein quantitative test(24 h),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),anticardiolipin antibody,serum creatinine level,course of the disease,and treatment regimens were collected.Thirty-five healthy people were set as the control group(group C).The levels of serum CD147 were measured by enzyme-linked immuno sorbent assay(ELISA)in 3 groups.The correlation between the serum CD147 level of SLE patients and atherosclerosis was analyzed.The statistical analysis was carried out with independent t-test,chi-square test,analysis of variance,Spearman correlation and Logistic regression.Results①Levels of serum CD147 in group A[(238±30)pg/ml]were significantly higher than those in group B[(198±30)pg/ml]and group C[(150±26)pg/ml,F=67.908,P<0.01].②Body mass index,hypertensive ratio,total blood cholesterol,urine protein quantitative test(24 h),systemic lupus erythematosus disease activity index(SLEDAI),serum CD147 index in group A were significantly higher than those in group B(P<0.05).③In Logistic regression analysis,serum CD147[OR(95%CI)=1.039(1.014,1.065),P<0.05],urine protein quantitative(24 h)[OR(95%CI)=2.598(1.033,6.534),P<0.05]were independently relevant factors affecting carotid artery IMT.Conclusion Serum CD147 is an independent risk factor for carotid intimamedia thickness in SLE patients.
作者
张秋双
闫秀清
葛风梅
李昭
赵敏
武雪
王学彬
Zhang Qiushuang;Yan Xiuqing;Ge Fengmei;Li Zhao;Zhao Min;Wu Xue;Wang Xuebin(Department of Rheumatology and Immunology,Binzhou Medical University Hospital,Shandong 256603,China)
出处
《中华风湿病学杂志》
CAS
CSCD
北大核心
2021年第4期236-240,共5页
Chinese Journal of Rheumatology
基金
山东省高等学校科技计划项目(J17KB081)。
