摘要
目的:分析左氧氟沙星注射液不良反应的发生原因与特点,为临床喹诺酮类药物的安全用药提供参考。方法:利用中国知网、万方数据和维普期刊网,检索近5年左氧氟沙星注射液不良反应案例报道38例资料,统计和分析其左氧氟沙星注射液致患者不良反应相关因素(患者性别、年龄和用药原因、给药剂量、不良反应的发生时间、不良反应的表现等)。结果:抽取的左氧氟沙星注射液不良反应报道37篇论文,涉及患者38例;其中中老年患者占65%以上,34%的患者在用药1 h内发生药物不良反应,其不良反应症状以皮肤过敏反应及中枢神经系统损害为主。结论:临床应严格按照左氧氟沙星注射液说明书规定的适应证与用法用量使用,用药60 min内应密切监测其不良反应的发生情况,以确保患者用药的安全性。
Objective: To analyze the causes and characteristics of adverse drug reactions(ADRs) induced by levofloxacin injection, and to provide reference for the safe use of quinolones. Methods: Data of 38 cases of adverse drug reactions of levofloxacin injection in the past 5 years were retrieved from CNKI, WANFANG and VPCS. The related factors of ADRs caused by levofloxacin injection(gender, age, cause of medication, dose, occurrence time of adverse reactions, its manifestations, etc.) were analyzed and investigated. Results: The adverse reactions of levofloxacin injection were reported in 37 papers, involving 38 academic patients. Among them, the middle-aged and elderly patients accounted for more than 65%, and 34% of the patients had ADRs within 1 hour after taking the drug, and the adverse reaction symptoms were mainly skin allergic reactions and damage to the central nervous system. Conclusion: The clinical medication should strictly follow the indications, usage and dosage of levofloxacin injection prescribed in the manual,and the occurrence of adverse reactions should be closely monitored within 60 min of the medication, so as to ensure the safety of the medication for patients.
作者
汤柳星
项铮
施爱明
潘杰
TANG Liu-xing;XIANG Zheng;SHI Ai-ming;PAN Jie(Department of Pharmacy,The No.2 Hospital Affiliated to Suzhou University,Suzhou Jiangsu 215004,China)
出处
《抗感染药学》
2021年第3期416-419,共4页
Anti-infection Pharmacy
关键词
氧氟沙星注射液
不良反应
喹诺酮类
案例报道
相关因素
levofloxacin injection
adverse drug reaction
quinolones
case reports
related factors
