摘要
哺乳动物体内普遍地存在丝裂原活化蛋白激酶,其简称为MAPK,属于丝/苏氨酸激酶类物质。它可以被物理应激、炎性细胞因子等多种细胞外信号的刺激而激活,通过各级磷酸化从而参与各细胞的增殖、分化等调节的多种生理反应。MAPK通路包含ERK1/2、JNK、p38MAPK以及ERK5通路,而c-Jun氨基末端蛋白激酶/应激活化蛋白激酶(JNK/SAPK)信号通路属于其中的一种,它参与支气管哮喘气道炎症、免疫功能以及气道重塑等病理环节,且中医药在治疗支气管哮喘过程中可以抑制各蛋白、各细胞因子的表达,从而达到治疗哮喘的目的,缓解患者的疾病痛苦,提高生活质量,改善精神状态。
Mitogen activated protein kinase(MAPK)is a kind of mitogen/threonine kinase in mammalian. It can be activated by a variety of extracellular signals,such as physical stress,inflammatory cytokines,and so on. Through phosphorylation at all levels,it participates in a variety of physiological responses regulated by cell proliferation and differentiation. MAPK pathway includes ERK1/2,JNK,p38 MAPK and ERK5 pathways,while c-Jun JNK/SAPK signal pathway is one of them. It is involved in airway inflammation,immune function,airway remodeling and other pathological links. In the process of treating asthma,traditional Chinese medicine can inhibit the expression of various proteins and cytokines,so as to achieve the purpose of treating asthma,relieve patients’ disease pain,improve their quality of life,and improve their mental state.
作者
邢江楠
吕英
朱振刚
XING Jiangnan;LYU Ying;ZHU Zhengang(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China)
出处
《辽宁中医药大学学报》
CAS
2021年第3期61-64,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金(8167150230)。
