Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response
被引量：4
摘要
Understanding interactions between the host and SARS-CoV-2 is essential for developing effective vaccines and therapeutics.Here,we report that SARS-CoV-2 usurps the host ubiquitin system to polyubiquitinate accessory protein ORF7a at Lys119.The 0RF7a polyubiquitination is primarily formed by K63-linked ubiquitin chains.
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